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Varied presentations of gastrointestinal stromal tumour

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Abstract

Gastrointestinal stromal tumours (GIST) are soft tissue tumours arising from the mesenchyma in the gastrointestinal tract. These are rare tumours. However, over the past few years with the better understanding of the pathogenesis of GIST and better imaging facilities, the diagnosis is made more frequently. The characteristic diagnostic feature of GIST is the expression of CD34 and receptor tyrosine kinase KIT, CD117 by these tumours. The use of tyrosine kinase inhibitor imatinib mesylate has led to improved outcome. The presentation of GIST however remains non-specific, and varies depending upon the size and the organ of origin. We present a series of four cases of GIST with varied presentation.

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References

  1. Kindblom LG (2003) Education session E 450. Oral presentation “Gastrointestinal stromal Tumours: Daignosis, Epedemiology, and Prognosis” in Gastrointestinal Stromal Tumours: Current management and Future challenges”. Chair: Blanke CD. ASCO

    Google Scholar 

  2. Rossi CR, Mocellin S, Mancarelli R et al (2003) Gastrointestinal Stromal Tumours: from a surgical to molecular approach. Int J Cancer 107:171–176

    Article  PubMed  CAS  Google Scholar 

  3. Mikhael AL, Bacchi CE, Zarbo RJ et al (1994) CD34 expression in stromal tumours of the Gastrointestinal tract. Appl Immunohistochemistry 2:89–93

    Google Scholar 

  4. Van de Rijn M, Hendrickson MR, Rouse RV (1994) The CD34 expression by the Gastrointestinal Stromal tumours. Hum Pathol 25:661–771

    Google Scholar 

  5. Romert P, Mikkelsen HB (1998) c- kit immunoreatcive interstitial cells of Cajal in the human small and large intestine. Histochem Cell Biol 09:195–202

    Google Scholar 

  6. Kindblom LG, Remotti HG, Aldenborg F et al (1999) Gastrointestinal pacemaker cell tumour (GIPACT): Gastrointestinal stromal tumours show phenotypic characteristic of the interstial cells of the Cajal. Am J Pathol 154:23–28

    Google Scholar 

  7. Sanders KM (1996) A case of interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the Gastrointestinal tract. Gastroentreology 111:492–515

    Article  CAS  Google Scholar 

  8. Fletcher CDM, Berman JJ, Corless C et al (2002) Diagnosis of Gastrointestinal stromal tumours: A consensus approach. Human Pathology 33:459–465

    Article  PubMed  Google Scholar 

  9. Miettinen M, Lasota J (2001) Gastrointestinal stromal Tumours-definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 438:1–12

    Article  PubMed  CAS  Google Scholar 

  10. Miettinen M, Sarlomo-Rikala M, Lasota J (1999) Gastrointestinal stromal Tumours: recent advances in understanding of their biology. Hum Pathol 30:1213–1220

    Article  PubMed  CAS  Google Scholar 

  11. Demetri GD (2001) Targeting c-kit mutations in solid tumour: scientific rationale and novel therapeutic options. Semin Oncol 28(suppl 17):19–26

    Article  PubMed  CAS  Google Scholar 

  12. Shabahang M, Livinstone AS (2002) Cutaneous metastasis from a Gastrointestinal stromal tumour of the stomach: Review of literature. Dig surg 19:64–65

    Article  PubMed  Google Scholar 

  13. Reichardt P (2003) Practical aspects of managing gastrointestinal stromal tumours. Monographs in Gastrointestinal stromal tumours 1:3–8

    Google Scholar 

  14. Berman J, O’Leary TJ (2001) Gastrointestinal stromal Tumour workshop: Hum Pathol 32:578–582

    CAS  Google Scholar 

  15. Eisenberg BL, Harris J, Blanke CD, Demetri GD, Heinrich MC, Watson JC et al (2008) Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumour (GIST): Early results of RTOG 0132/ACRIN 6665, J Surg Oncol [Epub ahead of print]

  16. Lehnert T (1998) Gastrointestinal sarcoma (GIST) — a review of surgical management. Ann Chir Gynecol 87:297–305

    CAS  Google Scholar 

  17. von Mehren M (2008) The role of adjuvant and neoadjuvant therapy in gastrointestinal stromal tumours. Curr Opin Oncol 20(4):428–432

    Article  CAS  Google Scholar 

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Correspondence to A. N. Supe.

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Kantharia, C.V., Irpatgire, R., Prabhu, R.Y. et al. Varied presentations of gastrointestinal stromal tumour. Indian J Surg 70, 318–321 (2008). https://doi.org/10.1007/s12262-008-0090-0

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  • DOI: https://doi.org/10.1007/s12262-008-0090-0

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