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Fabrication of degradable carboxymethyl cellulose (CMC) microneedle with laser writing and replica molding process for enhancement of transdermal drug delivery

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Abstract

Transdermal drug delivery system (TDDS) may provide a more reliable method of drug delivery than oral delivery by avoiding gut absorption and first-pass metabolism, but needs a method for efficiently crossing the epidermal barrier. To enhance the delivery through the skin, we have developed a biocompatible, dissolvable microneedle array made from carboxymethyl cellulose (CMC). Using laser ablation for creating the mold greatly improved the efficiency and reduced the cost of microneedle fabrication. Mixing CMC with amylopectin (AP) enhanced the mechanical and tunable dissolution properties of the microneedle for controlled release of model compounds. Using the CMC microneedle array, we observed significant enhancement in the skin permeability of a fluorescent model compound, and also increase in the anti-oxidant activity of ascorbic acid after crossing the skin. Our dissolvable microneedle array provides a new and biocompatible method for delivery of drugs and cosmetic compounds through the skin.

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Authors and Affiliations

  1. Department of Chemical Engineering, Hongik University, Seoul, 121-791, Korea

    Yong-Hun Park, Bumsang Kim & Jong Hwan Sung

  2. Korea Food Research Institute, Seongnam, Korea

    Sang Keun Ha & Inwook Choi

  3. Mizon, Osan, 447-210, Korea

    Kyu Sik Kim

  4. School of Urban and Civil Engineering, Hongik University, Seoul, 121-791, Korea

    Jeryang Park

  5. Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Korea

    Nakwon Choi

Authors
  1. Yong-Hun Park
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  2. Sang Keun Ha
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  3. Inwook Choi
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  4. Kyu Sik Kim
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  5. Jeryang Park
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  7. Bumsang Kim
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  8. Jong Hwan Sung
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Correspondence to Bumsang Kim.

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Park, YH., Ha, S.K., Choi, I. et al. Fabrication of degradable carboxymethyl cellulose (CMC) microneedle with laser writing and replica molding process for enhancement of transdermal drug delivery. Biotechnol Bioproc E 21, 110–118 (2016). https://doi.org/10.1007/s12257-015-0634-7

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  • DOI: https://doi.org/10.1007/s12257-015-0634-7

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