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Antioxidant activity of dihydrofurocoumarins from Corydalis heterocarpa

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Abstract

The aim of this paper is to report the results of investigations into the antioxidant effect of dihydrofurocoumarins (1–6), isolated from the salt marsh plant Corydalis heterocarpa. The scavenging activities of the isolated compounds against DPPH radicals, hydroxyl radicals, and superoxide radicals were evaluated by electron spin resonance. The protective activities of these compounds against hydroxyl radical-mediated genomic DNA damage and peroxynitrite-mediated dihydrorhodamine oxidation were also investigated. The experimental results show that most compounds had antioxidant activity but their capabilities differed a little for the different indicators. Among them, compound 6 exerted the strongest antioxidant activity at a concentration of 100 μM/mL for all tested bioassay systems, compared with other compounds.

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Authors and Affiliations

  1. Division of Marine Environment and Bioscience, Korea Maritime & Ocean University, Busan, 606-791, Korea

    You Ah Kim & Jung Im Lee

  2. Department of Food and Nutrition, Silla University, Busan, 617-736, Korea

    Chang-Suk Kong

  3. Department of Chemistry, Dongguk University-Seoul, Seoul, 100-715, Korea

    Joong Chul Choe

  4. Department of Architecture and Ocean Space, Korea Maritime & Ocean University, Busan, 606-791, Korea

    Kwang-suk Oh

  5. Division of Marine Environment and Bioscience, Korea Maritime & Ocean University, Busan, 606-791, Korea

    Youngwan Seo

  6. Ocean Science & Technology School, Korea Maritime & Ocean University, Busan, 606-791, Korea

    Youngwan Seo

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  1. You Ah Kim
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  2. Jung Im Lee
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Correspondence to Youngwan Seo.

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Kim, Y.A., Lee, J.I., Kong, CS. et al. Antioxidant activity of dihydrofurocoumarins from Corydalis heterocarpa . Biotechnol Bioproc E 19, 771–779 (2014). https://doi.org/10.1007/s12257-014-0462-1

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  • DOI: https://doi.org/10.1007/s12257-014-0462-1

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