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RETRACTED ARTICLE: MiR-184 Retarded the Proliferation, Invasiveness and Migration of Glioblastoma Cells by Repressing Stanniocalcin-2

  • Original Article
  • Published:
Pathology & Oncology Research

25 April 2024 Following publication, concerns were raised on the PubPeer platform regarding the validity of the data in the article. An investigation by the Editorial Office, conducted in accordance with Pathology and Oncology Research policies, was unable to confirm the validity of the data presented and as such cannot confirm its reliability. The article is therefore retracted. This retraction was approved by the Editor-in-Chief of Pathology and Oncology Research. The authors received communication regarding the retraction but did not respond. The communication has been recorded by the publisher. Pathology and Oncology Research would like to thank the concerned reader who contacted us regarding the published article.

Abstract

To investigate the repression of miR-184 on Stanniocalcin-2 (STC2) and how this axis affects the propagation, invasiveness and migration ability of glioblastoma cells. RT-PCR was employed to determine the miR-184 and STC2 mRNA expression both in tissues and cells. Western blot was employed to determine the protein expression levels. The cells were transfected via lipofection. MTT, colony formation, invasion and scratch healing assays were conducted to study the propagation, invasiveness and migratory ability of glioblastoma cells, respectively. The dual luciferase reporter gene assay was conducted to determine whether miR-184 could directly bind to STC2 mRNA 3’UTR. MiR-184 was under-expressed whereas STC2 was over-expressed in glioblastoma tissues and cell line. The up-regulation of miR-184 significantly suppressed the propagation, migratory ability and invasion of glioblastoma cells, whereas the over-expression of STC2 restored this effect. MiR-184 was confirmed to directly target STC2. MiR-184 could retard the propagation, invasiveness and migratory ability of glioblastoma cells by suppressing STC2.

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Change history

  • 25 April 2024

    Following publication, concerns were raised on the PubPeer platform regarding the validity of the data in the article. An investigation by the Editorial Office, conducted in accordance with Pathology and Oncology Research policies, was unable to confirm the validity of the data presented and as such cannot confirm its reliability. The article is therefore retracted. This retraction was approved by the Editor-in-Chief of Pathology and Oncology Research. The authors received communication regarding the retraction but did not respond. The communication has been recorded by the publisher. Pathology and Oncology Research would like to thank the concerned reader who contacted us regarding the published article.

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Author notes

  1. Linsen Feng and Jianhua Ma contributed equally to this work.

Authors and Affiliations

  1. Department of Neurosurgery, Taixing People’s Hospital, Taizhou, Jiangsu, 225400, China

    Linsen Feng, Jianhua Ma, Haiming Ji & Yichun Liu

  2. Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China

    Linsen Feng & Weixing Hu

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  1. Linsen Feng
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  2. Jianhua Ma
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  4. Yichun Liu
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  5. Weixing Hu
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Corresponding author

Correspondence to Weixing Hu.

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The research has been carried out in accordance with the World Medical Association Declaration of Helsinki.

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The authors declare that they have no conflict of interest.

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Feng, L., Ma, J., Ji, H. et al. RETRACTED ARTICLE: MiR-184 Retarded the Proliferation, Invasiveness and Migration of Glioblastoma Cells by Repressing Stanniocalcin-2. Pathol. Oncol. Res. 24, 853–860 (2018). https://doi.org/10.1007/s12253-017-0298-z

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  • DOI: https://doi.org/10.1007/s12253-017-0298-z

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