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Respiratory Motion, Anterior Heart Displacement and Heart Dosimetry: Comparison Between Prone (Pr) and Supine (Su) Whole Breast Irradiation

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Pathology & Oncology Research

Abstract

To analyze respiratory motion of surgical clips, chest wall (CW) and the anterior displacement of the heart and its impact on heart dosimetry between prone (Pr) and supine (Su) positions during whole breast radiotherapy after breast conserving surgery. Sixteen patients underwent 4D-CT for radiotherapy planning in Pr and Su positions. Maximum inhale and maximum exhale phases were analyzed. Mean 3D vectorial displacements ± standard deviations (SD) of the surgical clips were measured. Volumetric changes of the CW were recorded and compared. Cardiac displacement was assessed by a volume between the inner surface of CW and the myocardium of the heart (CW/H-V). For left-sided cases, comparative dosimetry was performed in each position simulating no- (Pr-noC, Su-noC) versus daily correction protocols (Pr-C, Su-C). The movements of 81 surgical clips were analyzed. Prone positioning significantly reduced both the mean 3D vectorial displacements (1.1 ± 0.6 (Pr) vs. 2.0 ± 0.9 mm (Su), p < 0.01) and their variability (0.3 ± 0.2 vs. 0.5 ± 0.3 mm, p = 0.01). Respiration-induced volumetric changes of CW were also significantly lower in Pr (2.3 ± 4.9 vs. 9.6 ± 7.1 cm3 , p < 0.01). The CW/H-V was significantly smaller in Pr than in Su (39.9 ± 14.6 vs. 64.3 ± 28.2 cm3 , p < 0.01). Besides identical target coverage heart, left-anterior-descending coronary artery (LADCA) and ipsilateral lung dose parameters were lowered with Pr-C compared to Pr-noC, Su-C and Su-noC. Prone position significantly reduced respiration-related surgical clip movements, their variability as well as CW movements. Significant anterior heart displacement was observed in Pr. Prone position with daily online correction could maximize the heart and LADCA protection.

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Authors and Affiliations

  1. Department of Radiation Oncology, University Hospital of Liège, Avenue de l’hôpital, B.35, 4000, Liège, Belgium

    Ferenc Lakosi, Akos Gulyban, Levente Janvary, Selma Ben-Mustapha Simoni, Nicolas Jansen & Philippe Coucke

  2. Department of Biostatistics, University Hospital of Liège, Liège, Belgium

    Laurence Seidel

  3. Department of Radiation Oncology, Kaposvar University, Kaposvar, Hungary

    Arpad Kovacs

  4. Department of Radiation Oncology, Hôpital Maisonneuve-Rosemont, Québec, Canada

    Peter Vavassis

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  1. Ferenc Lakosi
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  9. Philippe Coucke
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Correspondence to Ferenc Lakosi.

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Lakosi, F., Gulyban, A., Janvary, L. et al. Respiratory Motion, Anterior Heart Displacement and Heart Dosimetry: Comparison Between Prone (Pr) and Supine (Su) Whole Breast Irradiation. Pathol. Oncol. Res. 21, 1051–1058 (2015). https://doi.org/10.1007/s12253-015-9932-9

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  • DOI: https://doi.org/10.1007/s12253-015-9932-9

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