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Human Papillomavirus in Benign Prostatic Hyperplasia and Prostatic Adenocarcinoma Patients

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Pathology & Oncology Research

Abstract

The aim of this study was to determine the prevalence of human papillomavirus (HPV) types in tissue and HPV antibodies in prostatic disease. Prostate tissue samples were collected from 51 patients diagnosed with adenocarcinoma and 11 with benign prostatic hyperplasia (BPH). All tissue samples were confirmed by histology. Plasma samples were available for 52 prostate patients. We investigated HPV DNA prevalence by PCR, and PCR positive samples were HPV type determined by sequencing. Prevalence of antibodies against twenty-seven HPV proteins from fourteen different HPV types was assessed in the plasma samples. The HPV DNA prevalence in the tissue samples was 14% (7/51) for prostate cancer samples and 27% (3/11) for BPHs. HPV-18 was the only type detected in tissue samples (10/62). No significant difference in HPV prevalence between the prostate cancer and BPH samples was found. HPV-positive cells were identified in eight of our thirteen prostate tissue slides (3/3 BPH and 5/10 adenocarcinoma) by in situ hybridisation, and the positive cells were found in epithelial cells and peripheral blood cells. Serology data showed no significant increase in levels of antibodies against any of the HPV-18 proteins tested for in prostatic disease patients. Antibodies against HPV-1, HPV-4, HPV-6 and HPV-11 were significantly higher in the group of males with prostatic disease. Our study did not show an association between prostatic disease and either presence of HPV DNA in samples or previous exposure of high-risk HPV.

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Acknowledgements

We would like to thank all patients for their participation in the study.

Conflicting Interests

None.

Funding

The Sir Edward Dunlop Medical Research Foundation, the Prostate Cancer Foundation in Australia and the Mazda Foundation.

Ethical approval

This project was approved by the Princess Alexandra Hospital Human Research Ethics Committee (PAH 2005/060).

Author information

Author notes

  1. Annika Antonsson

    Present address: Genetics & Population Health Division, Queensland Institute of Medical Research, Brisbane, QLD, 4029, Australia

Authors and Affiliations

  1. The University of Queensland, Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Brisbane, QLD, 4102, Australia

    Alice C.-H. Chen, Annie Keleher, Denise McMillan, Nigel A. J. McMillan & Annika Antonsson

  2. Infection and Cancer Program, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany

    Tim Waterboer

  3. Department of Urology, Central Clinical Division, Princess Alexandra Hospital, The University of Queensland, Brisbane, QLD, 4102, Australia

    Beth Morrison & David Nicol

  4. Dame Roma Mitchell Cancer Research Laboratories, Adelaide, SA, 5000, Australia

    Shalini Jindal

  5. Department of Surgery, Central Clinical Division, Royal Brisbane Hospital, The University of Queensland, Brisbane, QLD, 4029, Australia

    Robert A. Gardiner

Authors
  1. Alice C.-H. Chen
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  2. Tim Waterboer
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  7. David Nicol
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  9. Nigel A. J. McMillan
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  10. Annika Antonsson
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Correspondence to Annika Antonsson.

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Chen, A.CH., Waterboer, T., Keleher, A. et al. Human Papillomavirus in Benign Prostatic Hyperplasia and Prostatic Adenocarcinoma Patients. Pathol. Oncol. Res. 17, 613–617 (2011). https://doi.org/10.1007/s12253-010-9357-4

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  • DOI: https://doi.org/10.1007/s12253-010-9357-4

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