Abstract
The aim of this study was to evaluate the expression of β-catenin in astrocytoma, and the clinical relevance and prognostic significance of the expression of β-catenin was also analyzed. Immunohistochemistry was performed on 63 resected astrocytoma tumor specimens to detect the expression of β-catenin. The correlation between the results of immuoexpression and the clinicopathologic parameters and patient survival was processed statistically. In 63 samples of astrocytoma, 36 cases were immunoreactive for β-catenin at cytoplasm, ten cases of astrocytoma were immunoreactive at cytomembrane, and four cases of astrocytoma were stained for β-catenin at nucleus. Spearman analysis showed that the distribution of β-catenin was not correlated with the grades of astrocytoma. However, the expression profiles were correlated with the patient’s 2-year survival, but not correlated with the grades, tumor size, sex, age, or tumor location. Patients with low β-catenin expression levels tended to be associated with a better prognosis than those who with high levels (p = 0.042). Our results suggest that β-catenin is useful for the prognosis evaluation of astrocytoma.
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Acknowledgements
This work was supported by the State Key Laboratory of Cancer Biology grant, China (CBSKL 2005004 to QL) and the National Natural Science Foundation of China (30671087 to QL and 30700268 to JY). We are grateful to Dr Rui Liu for help in statistical analysis, to members in Qing Li’s laboratories for technical assistance and helpful discussion.
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Zhang, LY., Jiang, LN., Li, FF. et al. Reduced β-catenin Expression is Associated with Good Prognosis in Astrocytoma. Pathol. Oncol. Res. 16, 253–257 (2010). https://doi.org/10.1007/s12253-009-9219-0
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DOI: https://doi.org/10.1007/s12253-009-9219-0