Abstract
Fibrous variant of Hashimoto’s thyroiditis (HT) is characterized by marked fibrous replacement of one third or more of the thyroid parenchyma. We present here three cases of mucosa associated lymphoid tissue (MALT) type lymphoma demonstrating prominent plasma cell differentiation resembling fibrous variant of HT. Histologically, thyroid structures were disturbed by a diffuse and focally nodular infiltration by mature plasma cells and cells with plasma cell differentiation against a background of prominent hyalinosis. In addition, scattered centrocyte-like (CCL) cells and lymphoepithelial lesions were observed in all three lesions. A portion of the resected specimens in all three cases exhibited HT. However, immunohistochemical study demonstrated that the plasma cells and CCL-cells of these three lesions had monotypic intracytoplasmic kappa light chain. Moreover, these three lesions demonstrated a clonal band on polymerase chain reaction assay for the immunoglobulin heavy chain gene. To avoid underdiagnosis, we emphasize that careful attention should be paid to these immunological features as well as to morphological findings.
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References
Hyjek E, Isaacson PG (1988) Primary B cell lymphoma of the thyroid and its relationship to Hashimoto’s thyroiditis. Hum Pathol 19:1315–1326
Isaacson PG, Norton AJ (1994) Extranodal lymphomas. Churchill Livingstone, Edinburgh
Katz SM, Vickery AL Jr (1974) The fibrous variant of Hashimoto’s thyroiditis. Hum Pathol 2:161–170
Harach HR, Williams ED (1983) Fibrous thyroiditis. An immunopathological study. Histopathology 7:739–751
Derringer GA, Thompson LDR, Frommelt RA et al (2000) Malignant lymphoma of the thyroid gland. A clinicopathologic study of 108 cases. Am J Surg Pathol 24:623–639
Wan JH, Trainor KJ, Brisco MJ et al (1990) Monoclonality in B cell lymphoma detected in paraffin wax embedded sections using the polymerase chain reaction. J Clin Pathol 43:888–890
Lennert K, Feller AC (1992) Histopathology of non-Hodgkin’s lymphomas (Based on the updated Kiel classification). Springer, Berlin
Hussong JW, Perkins SL, Schnitzer B et al (1999) Extramedullary plasmacytoma. A form of marginal zone cell lymphoma. Am J Clin Pathol 111:111–115
Kovacs CS, Mant MJ, Nguyen GK et al (1994) Plasma cell lesions of the thyroid: report of a case of solitary plasmacytoma and a review of the literature. Thyroid 4:65–71
Coffin CM, Watterson J, Priest JC et al (1995) Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 19:859–872
Coffin CM, Hornick JL, Fletcher CDM (2007) Inflammatory myofibroblastic tumor. Comparison of clinicopathologic, histologic, immunohistochemical features and ALK expression in atypical and aggressive cases. Am J Surg Pathol 31:509–520
Kriegel L, Guetgemann I, Zhou H (2007) Plasma cell granuloma of the thyroid gland mimicking carcinoma: A case report and review of the literature. Pathol Res Pract 203:813–817
Deniz K, Patrioğlu, Oketen T (2008) Plasma cell granuloma of the thyroid. Case report. APMIS 117:167–172
Kremer M, Ott G, Nathrath M et al (2005) Primary extramedullary plasmacytoma and multiple myeloma: Phenotypic differences revealed by immunohistochemical analysis. J Pathol 205:92–101
Feller AC, Diebold J (2003) Histopathology of nodal and extranodal non-Hodgkin's lymphomas. Springer, Berlin
Yatabe Y, Suzuki R, Matsuno Y et al (2001) Morphological spectrum of cyclin D-1 positive mantle cell lymphoma: study of 168 cases. Pathology International 51:747–761
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Kojima, M., Nakamura, N., Shimizu, K. et al. MALT Type Lymphoma Demonstrating Prominent Plasma Cell Differentiation Resembling Fibrous Variant of Hashimoto’s Thyroiditis: a Three Case Report. Pathol. Oncol. Res. 15, 285–289 (2009). https://doi.org/10.1007/s12253-008-9108-y
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DOI: https://doi.org/10.1007/s12253-008-9108-y