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A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China

  • Research article
  • Published:
Virologica Sinica

Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents.

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References

  • Anagnostou V, Papa A. 2009. Evolution of Crimean-Congo Hemorrhagic Fever virus. Infect Genet Evol, 9: 948–954.

    Article  CAS  Google Scholar 

  • Bereczky S, Lindegren G, Karlberg H, Akerstrom S, Klingstrom J, Mirazimi A. 2010. Crimean-Congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice. J Gen Virol, 91: 1473–1477.

    Article  CAS  Google Scholar 

  • Chen S. 2013. Molecular evolution of Crimean-Congo hemorrhagic fever virus based on complete genomes. J Gen Virol, 94: 843–850.

    Article  CAS  Google Scholar 

  • Dai X, Muhtar, Feng CH, Sun SR, Tai XP, Wang XH, Burenmind, Meng WW, Azat, Zhang YJ. 2006. Geography and host distribution of Crimean-Congo hemorrhagic fever in the Tarim Basin. Zhonghua Liu Xing Bing Xue Za Zhi, 27: 1048–1052. (In Chinese)

    CAS  PubMed  Google Scholar 

  • Deyde VM, Khristova ML, Rollin PE, Ksiazek TG, Nichol ST. 2006. Crimean-Congo hemorrhagic fever virus genomics and global diversity. J Virology, 80: 8834–8842.

    Article  CAS  Google Scholar 

  • Ergonul O. 2006. Crimean-Congo haemorrhagic fever. Lancet Infect Dis, 6: 203–214.

    Article  Google Scholar 

  • Feng CH, Bai XH, Liu HB, Li F, Gu Y. 1991. Discovery of Natural Foci of Xinjiang Hemorrhagic Fever in the Southern Margin Area of Junggar Basin, Xinjiang. Endemic Dis. Bull, 6: 52–55. (In Chinese)

    Google Scholar 

  • Gonzalez JP, Wilson ML, Cornet JP, Camicas JL. 1995. Host-passage-induced phenotypic changes in crimean-congo haemorrhagic fever virus. Res Virol, 146: 131–140.

    Article  CAS  Google Scholar 

  • Hewson R, Gmyl A, Gmyl L, Smirnova SE, Karganova G, Jamil B, Hasan R, Chamberlain J, Clegg C. 2004. Evidence of segment reassortment in Crimean-Congo haemorrhagic fever virus. J Gen Virol, 85: 3059–3070.

    Article  CAS  Google Scholar 

  • Papa A, Ma B, Kouidou S, Tang Q, Hang C, Antoniadis A. 2002. Genetic characterization of the M RNA segment of Crimean Congo hemorrhagic fever virus strains, China. Emerg Infect Dis, 8: 50–53.

    Article  CAS  Google Scholar 

  • Rodriguez LL, Maupin GO, Ksiazek TG, Rollin PE, Khan AS, Schwarz TF, Lofts RS, Smith JF, Noor AM, Peters CJ, Nichol ST. 1997. Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates. Am J Trop Med Hyg, 57: 512–518.

    Article  CAS  Google Scholar 

  • Schwarz TF, Nsanze H, Ameen AM. 1997. Clinical features of Crimean-Congo hemorrhagic fever in the United Arab Emirates. Infection, 25: 364–367.

    Article  CAS  Google Scholar 

  • Shepherd AJ, Swanepoel R, Leman PA, Shepherd SP. 1986. Comparison of methods for isolation and titration of Crimean-Congo hemorrhagic fever virus. J Clin Microbiol, 24: 654–656.

    Article  CAS  Google Scholar 

  • Sun S, Dai X, Aishan M, Wang X, Meng W, Feng C, Zhang F, Hang C, Hu Z, Zhang Y. 2009. Epidemiology and phylogenetic analysis of Crimean-Congo hemorrhagic fever viruses in xinjiang, china. J Clin Microbiol, 47: 2536–2543.

    Article  CAS  Google Scholar 

  • Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. 2013. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol, 30: 2725–2729.

    Article  CAS  Google Scholar 

  • Tang Q, Zhao XQ, Wang HY, Simayi B, Zhang YZ, Saijo M, Morikawa S, Liang GD, Kurane I. 2005. Molecular epidemiology of Xinjiang hemorrhagic fever viruses. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, 19: 312–318. (In Chinese)

    PubMed  Google Scholar 

  • Yen YC, Kong LX, Lee L, Zhang YQ, Li F, Cai BJ, Gao SY. 1985. Characteristics of Crimean-Congo hemorrhagic fever virus (Xinjiang strain) in China. Am J Trop Med Hyg, 34: 1179–1182.

    Article  CAS  Google Scholar 

  • Zhou Z, Deng F, Han N, Wang H, Sun S, Zhang Y, Hu Z, Rayner S. 2013a. Reassortment and migration analysis of Crimean-Congo haemorrhagic fever virus. J Gen Virol, 94: 2536–2548.

    Article  CAS  Google Scholar 

  • Zhou Z, Meng W, Deng F, Xia H, Li T, Sun S, Wang M, Wang H, Zhang Y, Hu Z. 2013b. Complete genome sequences of two crimean-congo hemorrhagic Fever viruses isolated in China. Genome Announc, 1. pii: e00571–13

    PubMed  PubMed Central  Google Scholar 

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Acknowledgments

This work was supported by the Science and Technology Basic Work Program (2013FY113500) from the Ministry of Science and Technology of China.

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Authors and Affiliations

  1. The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous’ Region, Urumqi, Xinjiang, 830002, China

    Rong Guo, Qiguo Wang, Zhihong Hu & Yujiang Zhang

  2. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China

    Shu Shen, Yanfang Zhang, Junming Shi, Zhengyuan Su, Jinliang Liu, Juan Yang & Fei Deng

  3. School of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, China

    Dan Liu

Authors
  1. Rong Guo
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  2. Shu Shen
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  3. Yanfang Zhang
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  4. Junming Shi
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  5. Zhengyuan Su
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  6. Dan Liu
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  7. Jinliang Liu
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  8. Juan Yang
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  9. Qiguo Wang
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  10. Zhihong Hu
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  11. Yujiang Zhang
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  12. Fei Deng
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Corresponding author

Correspondence to Yujiang Zhang.

Additional information

These authors contributed equally to this work.

ORCID: 0000-0001-9436-2595

ORCID: 0000-0002-5385-083X

Compliance with Ethics Guidelines

The authors declare that they have no conflict of interest. Animal experiments in this study were approved by the ethics committees of Wuhan Institute of Virology, Chinese Academy of Sciences (Approval number: WIVH01201 501).

Author Contributions

RG, JMS, JLL, ZYS, and QGW performed the ticks collection in Xinjiang and prepared the homogenates for newborn mice inoculation; RG and YFZ performed the mice inoculation and harvested the tissue samples, and performed the virus passage and IFA on cells; DL conducted the tissue sections from sacrificed mice and pathology analysis of CCHFV; ZYS and JY performed the CCHFV RNA detection in mice tissues. JMS and SS performed sequence of the genome with the phylogenetic analysis. YJZ and FD conceived of the study; RG and SS wrote the manuscript; YJZ and FD checked and finalized the manuscript.

Supplementary Table S1 is available on the websites of Virologica Sinica: www.virosin.org; link.springer.com/journal/12250.

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Guo, R., Shen, S., Zhang, Y. et al. A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China. Virol. Sin. 32, 80–88 (2017). https://doi.org/10.1007/s12250-016-3936-9

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  • DOI: https://doi.org/10.1007/s12250-016-3936-9

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