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Bacteriophage therapy against Enterobacteriaceae

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Virologica Sinica

Abstract

The Enterobacteriaceae are a class of gram-negative facultative anaerobic rods, which can cause a variety of diseases, such as bacteremia, septic arthritis, endocarditis, osteomyelitis, lower respiratory tract infections, skin and soft-tissue infections, urinary tract infections, intra-abdominal infections and ophthalmic infections, in humans, poultry, animals and fish. Disease caused by Enterobacteriaceae cause the deaths of millions of people every year, resulting in enormous economic loss. Drug treatment is a useful and efficient way to control Enterobacteriaceae infections. However, with the abuse of antibiotics, drug resistance has been found in growing number of Enterobacteriaceae infections and, as such, there is an urgent need to find new methods of control. Bacteriophage therapy is an efficient alternative to antibiotics as it employs a different antibacterial mechanism. This paper summarizes the history of bacteriophage therapy, its bacterial lytic mechanisms, and the studies that have focused on Enterobacteriaceae and bacteriophage therapy.

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Authors and Affiliations

  1. China National Research Institute of Food and Fermentation Industries, Beijing, 100015, China

    Youqiang Xu, Yong Liu, Yang Liu, Jiangsen Pei, Su Yao & Chi Cheng

  2. China Center of Industrial Culture Collection, Beijing, 100015, China

    Youqiang Xu, Yong Liu, Yang Liu, Jiangsen Pei, Su Yao & Chi Cheng

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  1. Youqiang Xu
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  2. Yong Liu
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  3. Yang Liu
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  5. Su Yao
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Correspondence to Chi Cheng.

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Xu, Y., Liu, Y., Liu, Y. et al. Bacteriophage therapy against Enterobacteriaceae . Virol. Sin. 30, 11–18 (2015). https://doi.org/10.1007/s12250-014-3543-6

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