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A multiple functional protein: the herpes simplex virus type 1 tegument protein VP22

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Virologica Sinica

Abstract

The herpes simplex virus type 1 (HSV-1) VP22, is one of the most abundant HSV-1 tegument proteins with an average stoichiometry of 2 400 copies per virion and conserved among alphaherpesvirinae. Many functions are attributed to VP22, including nuclear localization, chromatin binding, microtubule binding, induction of microtubule reorganization, intercellular transport, interaction with cellular proteins, such as template activating factor I (TAF-I) and nonmuscle myosin II A (NMIIA), and viral proteins including tegument protein VP16, pUS9 and pUL46, glycoprotein E (gE) and gD. Recently, many novel functions performed by the HSV-1 VP22 protein have been shown, including promotion of protein synthesis at late times in infection, accumulation of a subset of viral mRNAs at early times in infection and possible transcriptional regulation function.

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Authors and Affiliations

  1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China

    Mei-li Li, Hong Guo, Qiong Ding & Chun-fu Zheng

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  1. Mei-li Li
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  2. Hong Guo
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  3. Qiong Ding
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  4. Chun-fu Zheng
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Correspondence to Chun-fu Zheng.

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Foundation items: The Startup Fund of the Hundred Talents Program of the Chinese Academy of Science (20071010-141); National Natural Science Foundation of China (30870120); Open Research Fund Program of the State Key Laboratory of Virology of China (2007003, 2009007).

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Li, Ml., Guo, H., Ding, Q. et al. A multiple functional protein: the herpes simplex virus type 1 tegument protein VP22. Virol. Sin. 24, 153–161 (2009). https://doi.org/10.1007/s12250-009-3035-2

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  • DOI: https://doi.org/10.1007/s12250-009-3035-2

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