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Genetic analysis of the VP1 region of human enterovirus 71 strains isolated in Fuyang, China, during 2008

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Virologica Sinica

Abstract

Enterovirus 71 (EV71) is a common cause of Hand, foot, and mouth disease (HFMD) and may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis. To examine the genetic diversity of EV71, we determined and analyzed the complete VP1 sequences (891 nucleotides) from nine EV71 strains isolated in Fuyang, China. We found that nine EV71 strains isolated were over 98% homologous at the nucleotide level and 93%–100% homologous to members of the C4 subgenogroup. At the amino acid level, these Fuyang strains were 99%–100% homologous to one another, 97%–100% homologous to members of the C4 subgenogroup, and the histidine(H) at amino acid position 22 was conserved among the Fuyang strains. The results indicate that Fuyang isolates belong to genotype C4, and an H at position 22 appears to be a marker for the Fuyang strains.

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Authors and Affiliations

  1. Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, 650118, China

    Shao-hui Ma, Jian-sheng Liu, Jing-jing Wang, Hai-jing Shi, Hui-juan Yang, Jun-ying Chen, Long-ding Liu & Qi-han Li

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  1. Shao-hui Ma
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  2. Jian-sheng Liu
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  3. Jing-jing Wang
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  4. Hai-jing Shi
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  5. Hui-juan Yang
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  6. Jun-ying Chen
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  7. Long-ding Liu
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  8. Qi-han Li
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Correspondence to Qi-han Li.

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Foundation item: Scientific Research Fund of Institute of Pathogen Biology (2008IPB108)

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Ma, Sh., Liu, Js., Wang, Jj. et al. Genetic analysis of the VP1 region of human enterovirus 71 strains isolated in Fuyang, China, during 2008. Virol. Sin. 24, 162–170 (2009). https://doi.org/10.1007/s12250-009-3033-4

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  • DOI: https://doi.org/10.1007/s12250-009-3033-4

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