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Interference of hepatitis B virus with cellular signaling

  • Published:
Virologica Sinica

Abstract

The presence of hepatitis B virus (HBV) proteins leads to changes in the cellular gene expression. As a consequence, the cellular signaling processes are influenced by the actions of HBV proteins. It has been shown that HBV nucleocapsid protein and the amino-terminal part of polymerase termed as terminal protein (TP) could inhibit interferon signaling. Further, the global gene expression profiles differ in hepatoma cells with and without HBV gene expression and replication. The expression of interferon (IFN) stimulated genes (ISGs) was differently regulated in cells with HBV replication and could be modulated by antiviral treatments. The HBV TP has been found to modulate the ISG expression and enhance the HBV replication. The modulation of the cellular signaling processes by HBV may have significant implications for pathogenesis.

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Authors and Affiliations

  1. Institut für Virologie, Universitätsklinikum Essen, Essen, 45122, Germany

    Yang Xu, Chun-wei She, Xiao-yong Zhang & Meng-ji Lu

  2. Department of Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Yang Xu & Chun-wei She

  3. State Key Lab of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China

    Xiao-yong Zhang

  4. Graduate School of the Chinese Academy of Sciences, Beijing, 100072, China

    Xiao-yong Zhang

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  1. Yang Xu
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  2. Chun-wei She
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  3. Xiao-yong Zhang
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  4. Rong-juan Pei
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  5. Meng-ji Lu
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Correspondence to Meng-ji Lu.

Additional information

Foundation items: Deutsche Forschungsgemeinschaft (Lu 669/2-1, GRK1045/1, and Lu 669/5-1); Joint program of Deutscher Akademischer Austauschdienst and Chinese Academy of Science.

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Xu, Y., She, Cw., Zhang, Xy. et al. Interference of hepatitis B virus with cellular signaling. Virol. Sin. 23, 100–106 (2008). https://doi.org/10.1007/s12250-008-2940-0

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  • DOI: https://doi.org/10.1007/s12250-008-2940-0

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