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Research on hepatitis B virus genotypes and subgenotypes among Bai nationality in Dali, Yunnan Province

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Virologica Sinica

Abstract

To investigate the distribution of hepatitis B virus (HBV) genotypes and subgenotypes among the Bai nationality in Dali, a total of 100 serum samples from patients with chronic HBV-infection were collected for the detection of HBV genotypes and subgenotypes by genotype-specific primers and restriction fragment length polymorphism (RLFP), respectively. Among the 100 samples, the proportions of genotype B, C and mixed genotype (B+C) were 41%, 25% and 34%, respectively. All the genotype B strains belonged to subgenotype Ba. In genotype C, 84% were Subgenotype Cs and 12% were subgenotype Ce. The distribution of genotypes B, C and B+C showed no significant difference between male and female patients (P=0.182) and among the age groups of patients (P=0.812). The rates of HBeAg/HBeAg positivity were no significantly different among genotypes B, genotype C and mixed genotype (B+C) (P=0.077/P=0.663). In Dali, genotypes B, B+C and C existed among Bai nationality with chronic HBV-infection, and genotype B was the major genotype. Subgenotypes Ba and Cs were the predominant strains in patients with HBV genotype B/C infection. The most prominent characteristic was the higher prevalent rate of mixed genotype (B+C) in patients.

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Authors and Affiliations

  1. Department of Microbiology & Immunology, Dali University, Dali, 671000, China

    Wei Li, Yuan-ying Shen, Xuan-rong Zhang, Qiang Li, Ru Shen & Hai-ping Zhao

  2. Department of Microbiology & Immunology, Fenyang College of Shanxi Medical University, Fenyang, 032200, China

    Lai-feng Ren

Authors
  1. Wei Li
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  2. Yuan-ying Shen
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  3. Xuan-rong Zhang
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  4. Lai-feng Ren
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  5. Qiang Li
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  6. Ru Shen
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  7. Hai-ping Zhao
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Correspondence to Yuan-ying Shen.

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Foundation item: National Natural Science Foundation (30560136)

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Li, W., Shen, Yy., Zhang, Xr. et al. Research on hepatitis B virus genotypes and subgenotypes among Bai nationality in Dali, Yunnan Province. Virol. Sin. 23, 57–62 (2008). https://doi.org/10.1007/s12250-008-2923-1

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  • DOI: https://doi.org/10.1007/s12250-008-2923-1

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