Skip to main content

Advertisement

SpringerLink
Log in

Herpesvirus: an underestimated virus

  • Published:
Folia Microbiologica Aims and scope Submit manuscript

An Erratum to this article was published on 28 July 2017

This article has been updated

Abstract

Herpes simplex virus (HSV) infections are common and widespread; nevertheless, their outcome can be of unpredictable prognosis in neonates and in immunosuppressed patients. Anti-HSV therapy is effective, but the emergence of drug-resistant strains or the drug toxicity that hamper the treatment is of great concern. Vaccine has not yet shown relevant benefit; therefore, palliative prophylactic measures have been adopted to prevent diseases. This short review proposes to present concisely the history of HSV, its taxonomy, physical structure, and replication and to explore the pathogenesis of the infection, clinical manifestations, laboratory diagnosis, treatment, prophylaxis and epidemiology of the diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Change history

  • 28 July 2017

    An erratum to this article has been published.

References

  • Arduino PG, Porter SR (2008) Herpes simplex virus type 1 infection: overview on relevant clinico-pathological features. J Oral Pathol Med 37:107–121

    Article  PubMed  Google Scholar 

  • Brown AEC, Cohen MN, Tong S, Braverman RS, Roonev JF, Giller R, Levin MJ (2015) Pharmacokinetics and safety of intravenous cidofovir for life-threatening viral infections in pediatric hematopoietic stem cell transplant recipients. Antimicrob Agents Chemother 59:3718–3725

    Article  CAS  Google Scholar 

  • Butel JS (2012) Herpesvírus. In: Brooks GF, Carroll KC, Butel JS, Morse SA, Mietzner TA (eds) Microbiologia Médica de Jawetz, Melnick e Adelberg, 25th edn. AMGH, Porto Alegre, pp. 433–455

    Google Scholar 

  • Cardone G, Heymann JB, Cheng N, Trus BL, Steven AC (2012) Procapsid assembly, maturation, nuclear exit: dynamic steps in the production of infectious herpesvirions. Adv Exp Med Biol 726:423–439

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cardozo FT, Larsen IV, Carballo EV, Jose G, Stern RA, Brummel RC, Camelini CM, Rossi MJ, Simões CM, Brandt CR (2013) In vivo anti-herpes simplex virus activity of a sulfated derivate of Agaricus brasiliensis mycelial polysaccharide. Antimicrob Agents Chemother 57:2541–2549

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chentoufi AA, Kritzer E, Yu DM, Nesburn AB, Benmohamed L (2012) Towards a rational design of an asymptomatic clinical herpes vaccine: the old, the new, and the unknown. Clin Dev Immunol 1:1–16

    Google Scholar 

  • Di Giovine P, Settembre EC, Bhargava AK, Luftig MA, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C, Carfi A (2011) Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1. PLoS Patog 7:1–13

    Google Scholar 

  • Espada SF, Faccin-Galhardi LC, Rincão VP, Bernardi ALS, Lopes N, Longhini R, Mello JCP, Linhares REC, Nozawa C (2015) Antiviral activity of Trichilia catigua bark extracts for herpesvirus and poliovirus. Curr Pharm Biotechnol 16:1–9

    Article  CAS  Google Scholar 

  • Frobert E, Burrel S, Ducastelle-Lepretere S, Billaud G, Ader F, Casalegno JS, Nave V, Boutolleau D, Michallet M, Lina B, Morfin F (2014) Resistance of herpes simplex viruses to acyclovir: an update from a ten-year survey in France. Antivir Res 111:36–41

    Article  CAS  PubMed  Google Scholar 

  • Geller M, Neto MS, Ribeiro MG, Oliveira L, Naliato ECO, Abreu C, Schechtman RC (2012) Herpes simples: atualização clínica, epidemiológica e terapêutica. J Bras Doenças Sex Transm 24:260–266

    Article  Google Scholar 

  • Kim J (2011) Herpes simplex virus type 1 glycoprotein gm and the membrane associated protein UL11 are required for virus-induced cell fusion and efficient virus entry. Dissertation, Konkuk University

  • Kimberlin DW, Whitley RJ (2007) Antiviral therapy of HSV-1 and HSV-2. In: Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B, Whitley R, Yamanishi K (eds) Human herpesviruses: biology, therapy, and immunoprophylaxis, 1st edn. Cambridge University Press, Cambridge, pp. 1153–1174

    Chapter  Google Scholar 

  • Knipe DM, Cliffe A (2008) Chromatin control of herpes simplex virus lytic and latent infection. Nat Rev Microbiol 6:211–221

    Article  CAS  PubMed  Google Scholar 

  • Kukhanova MK, Korovina AN, Kochetkov SN (2014) Human herpes simplex virus: life cycle and development of inhibitors. Biochemistry 79:1635–1652

    CAS  PubMed  Google Scholar 

  • Legoff J, Péré H, Bélec L (2014) Diagnosis of genital herpes simplex virus infection in the clinical laboratory. Virol J 11:1–17

    Article  Google Scholar 

  • Li L, Qiu Z, Yan L, Liang F, Ye H, Cai Y, Guo W, Li Y, Yue J (2014) Herpes B virus gD interaction with its human receptor—an in silico analysis approach. Theor Biol Med Model 11:1–16

    Google Scholar 

  • Lopes N (2012) Avaliação da atividade antiviral de um polissacarídeo sulfatado de Caesalpinia ferrea e do flavonoide quercetina contra o vírus herpes simplex tipo 1 (HSV-1). Dissertação, Universidade Estadual de Londrina

  • Murray PR, Rosenthal KS, Pfaller MA (2015) Medical microbiology. Elsevier, Rio de Janeiro

  • Penello AM, Campos BC, Simão MS, Gonçalves MS, Souza PMT, Salles RS, Pellegrini E (2010) Herpes Ggnital. J Bras Doenças Sex Transm 22:64–72

    Article  Google Scholar 

  • Prasad KM, Watson AM, Dickerson FB, Yolken RH, Nimgaonkar VL (2012) Exposure to herpes simplex virus type 1 and cognitive impairments in individuals with schizophrenia. Schizophr Bull 38:1137–1148

    Article  PubMed  PubMed Central  Google Scholar 

  • Reil H, Bartlime A, Drerup J, Grewing T, Korn K (2008) Clinical validation of a new triplex real-time polymerase chain reaction assay for the detection and discrimination of herpes simplex virus types 1 and 2. J Mol Diagn 10:361–367

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roizman B, Knipe DM, Whitley RJ (2007) Herpes simplex viruses. In: Knipe DM, Howley PM (eds) Fields Virology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pp. 2502–2601

    Google Scholar 

  • Roizman B, Whitley RJ (2013) An inquiry into the molecular basis of HSV latency and reactivation. Annu Rev Microbiol 67:355–374

    Article  CAS  PubMed  Google Scholar 

  • Santos MPM, Morais MPLA, Fonseca DDD, Faria ABS, Silva IHM, Carvalho AAT, Leão JC (2012) Herpesvírus humano: tipos, manifestações orais e tratamento. Odontol Clín-Cient 11:191–196

    Google Scholar 

  • Silva S, Bowers WJ (2009) Herpes virus amplicon vectors. Viruses 1:594–629

    Article  PubMed  PubMed Central  Google Scholar 

  • Torres NI, Castilla V, Bruttomesso AC, Eiras J, Galagovsky LR, Wachsman MB (2012) In vitro antiviral activity of dehydroepiandrosterone, 17 synthetic analogs and ERK modulators against herpes simplex virus type 1. Antivir Res 95:37–48

    Article  CAS  PubMed  Google Scholar 

  • Whitley RJ (2014) Herpes simplex virus. In: Scheld WM, Whitley RJ, Marra CM (eds) Infections of the central nervous system, 4th edn. Lippincott Williams & Wilkins, Philadelfia, pp. 137–156

    Google Scholar 

  • Wigg MD, Miranda MMFS (2008) Viroses dermotrópicas. In: Santos NOS, Romanos MTV, Wigg MD (eds) Introdução à Virologia Humana, 2nd edn. Guanabara Koogan, Rio de Janeiro, pp. 177–211

    Google Scholar 

  • World Health Organization (2015) Herpes simplex virus. http://www.who.int/mediacentre/factsheets/fs400/en/. Accessed 31 Jan 2016

  • Woster PM (2012) Antiviral agents and protease inhibitors. In: Lemke TL, Williams DA, Roche VF, Zito SW (eds) Foye’s principles of medicinal chemistry, 7th edn. Lippincott Williams & Wilkins, Philadelphia, pp. 1267–1308

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departamento de Microbiologia, Laboratório de Virologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Campus Universitário, Rod. Celso Garcia Cid, (Pr 445), km 380, Bairro: Jardim Portal de Versalhes, Londrina, Paraná, CEP: 86051-970, Brazil

    Daniele Zendrini Rechenchoski, Ligia Carla Faccin-Galhardi, Rosa Elisa Carvalho Linhares & Carlos Nozawa

Authors
  1. Daniele Zendrini Rechenchoski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ligia Carla Faccin-Galhardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rosa Elisa Carvalho Linhares
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Carlos Nozawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniele Zendrini Rechenchoski.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

An erratum to this article is available at https://doi.org/10.1007/s12223-017-0539-2.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rechenchoski, D.Z., Faccin-Galhardi, L.C., Linhares, R.E.C. et al. Herpesvirus: an underestimated virus. Folia Microbiol 62, 151–156 (2017). https://doi.org/10.1007/s12223-016-0482-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12223-016-0482-7

Keywords

Search

Navigation