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The oral microbiome diversity and its relation to human diseases

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Abstract

As one of the most clinically relevant human habitats, the human mouth is colonized by a set of microorganisms, including bacteria, archaea, fungi, and viruses. Increasing evidence has supported that these microbiota contribute to the two commonest oral diseases of man (dental caries and periodontal diseases), presenting significant risk factors to human health conditions, such as tumor, diabetes mellitus, cardiovascular diseases, bacteremia, preterm birth, and low birth weight in infants. It is widely accepted that oral microorganisms cause diseases mainly by a synergistic or cooperative way, and the interspecies interactions within the oral community play a crucial role in determining whether oral microbiota elicit diseases or not. Since a comprehensive understanding of the complex interspecies interactions within a community needs the knowledge of its endogenous residents, a plenty of research have been carried out to explore the oral microbial diversity. In this review, we focus on the recent progress in this field, including the oral microbiome composition and its association with human diseases.

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Acknowledgments

This work was supported by the International Science and Technology Cooperation Program of China (grant number 2011DFA30940), the National Basic Research Program of China (“973 Pilot Research Program,” grant number 2011CB512108), project supported by the National Natural Science Foundation of China (grant numbers 30901689 and 81172579), and Sichuan Provincial Department of Science and Technology project (2013SZ0039).

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China

    Jinzhi He, Yan Li, Yangpei Cao, Jin Xue & Xuedong Zhou

  2. Department of Endodontics and Operative Dentistry, West China Hospital of Stomatology, Chengdu, China

    Jinzhi He, Yangpei Cao, Jin Xue & Xuedong Zhou

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  1. Jinzhi He
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  2. Yan Li
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  3. Yangpei Cao
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  4. Jin Xue
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Correspondence to Xuedong Zhou.

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Jinzhi He and Yan Li have equal contribution to this work.

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He, J., Li, Y., Cao, Y. et al. The oral microbiome diversity and its relation to human diseases. Folia Microbiol 60, 69–80 (2015). https://doi.org/10.1007/s12223-014-0342-2

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