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Antibacterial activity of N-benzylsalicylthioamides

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Abstract

The in-vitro biological activity of N-benzylsalicylthioamides against 8 bacterial strains was determined by broth microdilution method; results were compared with those obtained with neomycin, penicillin G, ciprofloxacin and penicillin V. The compounds showed moderate to high activity against G+ bacteria; especially compounds 4, 6, 13, 16–21 and 24 exhibited comparable or higher activity than reference drugs. The antibacterial activity was analyzed by quantitative structure-activity relationship (QSAR). The antibacterial activity increased with lipophilicity, with the presence of halogens and with increasing value of Hammet substituent constant σ.

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Abbreviations

24/48 h:

24 or 48 h incubation

Cip:

ciprofloxacin

F :

Fischer-Snedecor F-test

IP:

indicator parameter

log P :

partition coefficient (octanol-water)

MHA:

Mueller-Hinton agar

MIC:

minimum inhibitory concentration, μmol/L

n :

number of compounds used for the calculation

Neo:

neomycin

PenG:

penicillin G (benzylpenicillin)

PenV:

penicillin V (phenoxymethylpenicillin)

QSAR:

quantitative structure-activity relationship

R :

correlation coefficient

SD:

standard deviation

WHO:

World Health Organisation

σ :

Hammet constant

References

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Authors and Affiliations

  1. Department of Inorganic and Organic Chemistry, Charles University in Prague, 500 03, Hradec Králové, Czechia

    E. Petrlíková & K. Waisser

  2. Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, 500 03, Hradec Králové, Czechia

    P. Jílek & I. Dufková

Authors
  1. E. Petrlíková
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  2. K. Waisser
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  3. P. Jílek
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  4. I. Dufková
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Corresponding author

Correspondence to K. Waisser.

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Petrlíková, E., Waisser, K., Jílek, P. et al. Antibacterial activity of N-benzylsalicylthioamides. Folia Microbiol 55, 418–421 (2010). https://doi.org/10.1007/s12223-010-0070-1

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  • DOI: https://doi.org/10.1007/s12223-010-0070-1

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