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Antimicrobial, Antibiofilm and Cytotoxicity Activity of a New Acridine Hyperbranched Polymer in Solution and on Cotton Fabric

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Abstract

For the first time a fluorescent hyperbranched polymer modified with acridine (P1000-Acrid) was tested in vitro for antimicrobial activity against different model pathogens. The results showed strong activity of the compound against the used Gram-positive and Gram negative bacteria and yeasts. Cytotoxicity effect of P1000-Acrid has been studied towards HEp-2 cell line. The antibacterial finishing of cotton fabric treated with the P1000-Acrid was evaluated towards Grampositive and Gram-negative bacteria. It has been shown that the studied P1000-Acrid polymer reduces bacterial growth and prevents the formation of biofilm. The obtained results indicate that the studied P1000-Acrid hyperbranched polymer possess good antimicrobial potential with the greatest effectiveness against the used Gram-positive strains.

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Authors and Affiliations

  1. The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria

    Evgenia Vasileva-Tonkova, Petar Grozdanov & Ivanka Nikolova

  2. University of Chemical Technology and Metallurgy, Sofia, 1756, Bulgaria

    Desislava Staneva

  3. Institute of Science and Technology of Polymers, ICTR-CSIC, Madrid, 28006, Spain

    Sandra Medel & Paula Bosch

  4. Faculty of Medicine, Sofia University “St. Kliment Ohridski”, Sofia, 1407, Bulgaria

    Ivo Grabchev

Authors
  1. Evgenia Vasileva-Tonkova
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  2. Desislava Staneva
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  3. Sandra Medel
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  4. Paula Bosch
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  5. Petar Grozdanov
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  6. Ivanka Nikolova
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  7. Ivo Grabchev
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Correspondence to Evgenia Vasileva-Tonkova or Ivo Grabchev.

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Vasileva-Tonkova, E., Staneva, D., Medel, S. et al. Antimicrobial, Antibiofilm and Cytotoxicity Activity of a New Acridine Hyperbranched Polymer in Solution and on Cotton Fabric. Fibers Polym 20, 19–24 (2019). https://doi.org/10.1007/s12221-019-8687-4

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  • DOI: https://doi.org/10.1007/s12221-019-8687-4

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