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Effect of dextran on rheological properties of rat blood

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Abstract

There has been little information available on how the use of dextran in vivo influences plasma viscosity and yield stress of blood. Hence, the main purpose of this study is to provide such information when level of red blood cell aggregation in rats was raised to levels seen in normal human blood with administration of Dextran 500. Our results show that plasma viscosity (P < 0.003) and yield stress (P < 0.01) of rat blood increased significantly after dextran infusion. Whole blood viscosity also significantly increased with the dextran treatment over the entire range of shear rates we measured. The viscosity changes at high shear rates after dextran infusion would be due mainly to elevation of plasma viscosity, whereas the changes at low shear rates would be attributed to red blood cell aggregation induced by the dextran treatment.

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Authors and Affiliations

  1. Division of Bioengineering and Department of Surgery, National University of Singapore, Singapore, 117574, Singapore

    Sangho Kim & Shihong Yang

  2. Gerontechnology Center, Korea Institute of Industrial Technology, Chungnam, 330-825, Korea

    Dohyung Lim

Authors
  1. Sangho Kim
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  2. Shihong Yang
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  3. Dohyung Lim
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Correspondence to Dohyung Lim.

Additional information

This paper was recommended for publication in revised form by Associate Editor Haecheon Choi

Sangho Kim received his B.S. degree in Mechanical Engineering from Kyung-Pook National University in 1997. He then received his Ph.D. degree from Drexel University, USA, in 2002. Dr. Kim is currently an Assistant Professor in the Division of Bioengineering and the Department of Surgery at the National University of Singapore in Singapore.

Shihong Yang received his B.S. degree in Bioengineering from the National University of Singapore, Singapore, in 2007. He is currently a research engineer in the Division of Bioengineering, National University of Singapore, Singapore.

Dohyung Lim received B.S. and M.S. degrees in Biomedical Engineering from Inje University, Kimhae, Korea, in 1998 and 2000, respectively. He then went on to receive his Ph.D. degree from the School of Biomedical Engineering, Science, & Health Systems, Drexel University, Philadelphia, PA, USA, in 2004. Dr. Lim completed a postdoctoral fellowship in the Department of Physical Therapy and Human Movement Science, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA and as a Research Professor of Biomedical Engineering, Yonsei University, Wonju, Gangwon, Korea. Dr. Lim is currently a Senior Researcher at the Korea Institute of Industrial Technology in Cheonan, Chungnam, Korea.

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Kim, S., Yang, S. & Lim, D. Effect of dextran on rheological properties of rat blood. J Mech Sci Technol 23, 868–873 (2009). https://doi.org/10.1007/s12206-009-0211-0

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  • DOI: https://doi.org/10.1007/s12206-009-0211-0

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