Abstract
We investigated the effect of magnesium chloride (MgCl2) on the nuclear magnetic resonance dose–response of polyacrylamide-type (PAGAT, NIPAM, and VIPET) gel dosimeters containing acrylamide, N-isopropylacrylamide, and N-vinylpyrrolidone as a monomer, respectively. The dose-transverse relaxation rates (1/T2 = R2) obtained from magnetic resonance imaging data revealed that a substantial increase in the dose–R2 response occurred as the concentration of MgCl2 in the gel dosimeters increased. The sensitivity of the PAGAT gel with 1.0 M MgCl2 was found to be approximately one order higher than that of the same gel without MgCl2. In addition, the water equivalences of the gels with MgCl2 were evaluated over a wide range of photon energies. The results indicated that MgCl2 acts as a powerful sensitizer to radiation-induced free-radical polymerization in polyacrylamide-type gel dosimeters, but does not interfere with the desirable properties of basic polyacrylamide-type gel dosimeters (i.e., the dose rate and dose integration).
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References
Ibbott GS. Clinical applications of gel dosimeters. J Phys Conf Ser. 2006;56:108–31.
Maryanski MJ, Gore JC, Kennan RP, Schulz RJ. NMR relaxation enhancement in gels polymerized and cross-linked by ionizing radiation: a new approach to 3D dosimetry by MRI. Magn Reson Imaging. 1993;11:253–8.
Maryanski MJ, Zastavker YZ, Gore JC. Radiation dose distributions in three dimensions from tomographic optical density scanning of polymer gels: II. Optical properties of the BANG polymer gel. Phys Med Biol. 1996;41:2705–17.
Hilts M, Audet C, Duzenli C, Jirasek A. Polymer gel dosimetry using X-ray computed tomography: a feasibility study. Phys Med Biol. 2000;44:2559–71.
Baldock C, De Deene Y, Doran S, Ibbott G, Jirasek A, Lepage M, McAuley KB, Oldham M, Schreiner LJ. Polymer gel dosimetry. Phys Med Biol. 2010;55:R1–63.
De Deene Y, Vergote K, Claeys C, De Wagter C. The fundamental radiation properties of normoxic polymer gel dosimeters: a comparison between a methacrylic acid based gel and acrylamide based gels. Phys Med Biol. 2006;51:653–73.
Karlsson A, Gustavsson H, Månsson S, McAuley KB, Bäck SÅJ. Dose integration characteristics in normoxic polymer gel dosimetry investigated using sequential beam irradiation. Phys Med Biol. 2007;52:4697–706.
Koeva VI, Olding T, Jirasek A, Schreiner LJ, McAuley KB. Preliminary investigation of the NMR, optical and X-ray CT dose-response of polymer gel dosimeters incorporating cosolvents to improve dose sensitivity. Phys Med Biol. 2009;54:2779–90.
Jirasek A, Hilts M, McAuley KB. Polymer gel dosimeters with enhanced sensitivity for use in X-ray CT polymer gel dosimetry. Phys Med Biol. 2010;55:5269–281.
Kozicki M, Jaszczak M, Maras P, Dudek M, Cłapa M. On the development of a VIPARnd radiotherapy 3D polymer gel dosimeter. Phys Med Biol. 2017;62:986–1008.
Chain JNM, Jirasek A, Schreiner LJ, McAuley KB. Cosolvent-free polymer gel dosimeters with improved dose sensitivity and resolution for X-ray CT dose response. Phys Med Biol. 2011;56:2091–102.
Hayashi S, Fujiwara F, Usui S, Tominaga T. Effect of inorganic salt on the dose sensitivity of polymer gel dosimeter. Radiat Phys Chem. 2012;81:884–8.
Kolokolkina NV, Penenzhik MA, Virnik AD, Martynenko AI, Yanovskii YG, Topchiev DA, Kabanov VA. Effect of inorganic salts on reaction rate in high-conversion polymerization of N-trimethylammoniumethyl methacrylate methyl sulphate in aqueous solutions. Polym Sci USSR. 1986;28:166–70.
Hayashi S, Kawamura H, Usui S, Tominaga T. Comparison of the influence of inorganic salts on the NMR dose sensitivity of polyacrylamide-based gel dosimeter. J Phys Conf Ser. 2013;444:012094.
Venning AJ, Hill B, Brindha S, Healy BJ, Baldock C. Investigation of the PAGAT polymer gel dosimeter using magnetic resonance imaging. Phys Med Biol. 2005;50:3875–88.
Senden RJ, De Jean P, McAuley KB, Schreiner LJ. Polymer gel dosimeters with reduced toxicity: a preliminary investigation of the NMR and optical dose–response using different monomers. Phys Med Biol. 2006;51:3301–14.
Papadakis AE, Maris TG, Zacharopoulou F, Pappas E, Zacharakis G, Damilakis J. An evaluation of the dosimetric performance characteristics of N-vinylpyrrolidone-based polymer gels. Phys Med Biol. 2007;52:5069–83.
Pavoni JF, Baffa O. An evaluation of dosimetric characteristics of MAGIC gel modified by adding formaldehyde-MAGIC-f. Radiat Meas. 2012;47:1074–82.
Berger MJ, Hubbell JH, Seltzer SM, Chang J, Coursey JS, Sukumar R, Zucker DS, Olsen K. XCOM: photon cross sections database, web ver. 1.5. National Institute of Standards and Technology, Gaithersburg; 2010. http://www.nist.gov/pml/data/xcom/index.cfm. Accessed 3 Jan 2018.
Taylor ML, Smith RL, Dossing F, Franich RD. Robust calculation of effective atomic numbers: the Auto-Z eff software. Med Phys. 2012;39:1769–78.
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Hayashi, Si., Kawamura, H., Usui, S. et al. Influence of magnesium chloride on the dose–response of polyacrylamide-type gel dosimeters. Radiol Phys Technol 11, 375–381 (2018). https://doi.org/10.1007/s12194-018-0473-2
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DOI: https://doi.org/10.1007/s12194-018-0473-2