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Quantitation of specific binding ratio in 123I-FP-CIT SPECT: accurate processing strategy for cerebral ventricular enlargement with use of 3D-striatal digital brain phantom

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Abstract

This study aimed to evaluate the effect of ventricular enlargement on the specific binding ratio (SBR) and to validate the cerebrospinal fluid (CSF)-Mask algorithm for quantitative SBR assessment of 123I-FP-CIT single-photon emission computed tomography (SPECT) images with the use of a 3D-striatum digital brain (SDB) phantom. Ventricular enlargement was simulated by three-dimensional extensions in a 3D-SDB phantom comprising segments representing the striatum, ventricle, brain parenchyma, and skull bone. The Evans Index (EI) was measured in 3D-SDB phantom images of an enlarged ventricle. Projection data sets were generated from the 3D-SDB phantoms with blurring, scatter, and attenuation. Images were reconstructed using the ordered subset expectation maximization (OSEM) algorithm and corrected for attenuation, scatter, and resolution recovery. We bundled DaTView (Southampton method) with the CSF-Mask processing software for SBR. We assessed SBR with the use of various coefficients (f factor) of the CSF-Mask. Specific binding ratios of 1, 2, 3, 4, and 5 corresponded to SDB phantom simulations with true values. Measured SBRs > 50% that were underestimated with EI increased compared with the true SBR and this trend was outstanding at low SBR. The CSF-Mask improved 20% underestimates and brought the measured SBR closer to the true values at an f factor of 1.0 despite an increase in EI. We connected the linear regression function (y = − 3.53x + 1.95; r = 0.95) with the EI and f factor using root-mean-square error. Processing with CSF-Mask generates accurate quantitative SBR from dopamine transporter SPECT images of patients with ventricular enlargement.

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Acknowledgements

This study was supported by the Digital Image Scientific Research Meeting (Mihara, Hiroshima, Japan).

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Authors and Affiliations

  1. Department of Radiological Technology, Hiroshima Citizens Asa Hospital, 1-1, Kabeminami, Asakita-ku, Hiroshima, Hiroshima, 731-0293, Japan

    Akihiro Furuta

  2. Program in Health and Welfare, Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, 1-1, Gakuenmachi, Mihara, Hiroshima, 723-0053, Japan

    Akihiro Furuta & Hideo Onishi

  3. Graduate School of Nursing, Hyogo University of Health Sciences, 1-3-6, Minatojima, Chuo-ku, Kobe, Hyogo, 650-8530, Japan

    Hizuru Amijima

Authors
  1. Akihiro Furuta
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  2. Hideo Onishi
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Correspondence to Hideo Onishi.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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This article does not contain any studies with animals performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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All other authors declare that they have no conflicts of interest.

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Furuta, A., Onishi, H. & Amijima, H. Quantitation of specific binding ratio in 123I-FP-CIT SPECT: accurate processing strategy for cerebral ventricular enlargement with use of 3D-striatal digital brain phantom. Radiol Phys Technol 11, 219–227 (2018). https://doi.org/10.1007/s12194-018-0459-0

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  • DOI: https://doi.org/10.1007/s12194-018-0459-0

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