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Correction of liver displacement due to irregular respiration for SPECT images obtained using a multiple short-time acquisition with breath-holding technique

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Abstract

Recently, a new method for acquiring single photon emission computed tomography (SPECT) data during breath-holding with a high-speed rotation (HSR-SPECT) technique was applied to hepatic-function scintigraphy. This technique can suppress motion artifact caused by respiration. However, it is challenging to apply this technique to patients with respiratory problems. Our purpose in this study was to analyze projection data and correct liver displacement due to irregular respiration during technetium-99m-diethylenetriaminepentaacetic acid galactosyl human serum albumin (99mTc-GSA) liver SPECT scans. We calculated cross-correlation functions (CCFs) for both intra- and inter-projections to correct irregular projections by shifting them in the longitudinal direction enough to maximize the CCFs. We integrated all of the shifted projections and created a synthesis projection which was used to reconstruct SPECT images. To confirm the effectiveness of our method, we did both a phantom study and a clinical retrospective review. In the phantom study, blurring artifacts due to displacement were reduced using our method. Post-processing using our method showed improvements in the normalized mean square error values ranging from 0.18 to 0.06. Furthermore, our method showed no disadvantage or miss-correction if we applied our method to data without displacement. In the clinical review, our method improved the image clarity for patients who could not repeat consistent respiration. In both the phantom simulation and the clinical application, the results showed the usefulness of our method. The efficiency of our method has the potential to reduce the displacement problem caused by respiration and provides excellent matching SPECT/CT fusion images.

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References

  1. Yumoto Y, Yagi T, Sato S, Nouso K, Kobayashi Y, Ohmoto M, Yumoto E, Nagaya I, Nakatsukasa H. Preoperative estimation of remnant hepatic function using fusion images obtained by (99m)Tc-labelled galactosyl-human serum albumin liver scintigraphy and computed tomography. Br J Surg. 2010;97(6):934–44.

    Article  PubMed  CAS  Google Scholar 

  2. Iimuro Y, Kashiwagi T, Yamanaka J, Hirano T, Saito S, Sugimoto T, Watanabe S, Kuroda N, Okada T, Asano Y, Uyama N, Fujimoto J, et al. Preoperative estimation of asialoglycoprotein receptor expression in the remnant liver from CT/99mTc-GSA SPECT fusion images correlates well with postoperative liver function parameters. J Hepatobiliary Pancreatic Sci. 2010;17(5):673–81.

    Article  Google Scholar 

  3. de Graaf W, Bennink RJ, Veteläinen R, van Gulik TM. Nuclear imaging techniques for the assessment of hepatic function in liver surgery and transplantation. J Nucl Med. 2010;51(5):742–52.

    Article  PubMed  Google Scholar 

  4. Dey J, Segars WP, Pretorius PH, Walvick RP, Bruyant PP, Dahlberg S, King MA, et al. Estimation and correction of cardiac respiratory motion in SPECT in the presence of limited-angle effects due to irregular respiration. Med Phys. 2010;37(12):6453–65.

    Article  PubMed  Google Scholar 

  5. Kovalski G, Israel O, Keidar Z, Frenkel A, Sachs J, Azhari H. Correction of heart motion due to respiration in clinical myocardial perfusion SPECT scans using respiratory gating. J Nucl Med. 2007;48(4):630–6.

    Article  PubMed  Google Scholar 

  6. Wilson MA, Gaines J. Correction of respiratory motion in hepatic scintigraphy. J Clin Nucl Med. 1981;6(8):372–4.

    Article  CAS  Google Scholar 

  7. Turner DA, Fordham EW, Ali A, Rubin PD, Muerhrcke RC, Oppenheim BE, Yasillo NJ, Sukerkar AN, Novetsky GJ, Dalia DP, Hoffer PB. Motion corrected hepatic scintigraphy: an objective clinical evaluation. J Nucl Med. 1978;19(2):142–8.

    PubMed  CAS  Google Scholar 

  8. Ue H, Haneishi H, Iwanaga H, Suga K, et al. Respiratory lung motion analysis using a nonlinear motion correction technique for respiratory-gated lung perfusion SPECT images. Ann Nucl Med. 2007;21(3):175–83.

    Article  PubMed  Google Scholar 

  9. Yonezawa T, Koike M, Oishi Y, Iwanaga H. Application of breath-holding SPECT with high-speed-rotation technique in hepatic-function scintigraphy. Radiol Phys Technol. 2008;1(2):234–7.

    Article  PubMed  Google Scholar 

  10. Iwanaga H, Oishi Y, Suga K. Development of a new method of high-speed rotation multiplied projection single photon emission computed tomography of the triple-headed type: lung MAA SPECT based on phantom study. Nippon Hoshasen Gijutsu Gakkai Zasshi. 2006;62(6):848–54.

    Article  Google Scholar 

  11. Oishi Y, Iwanaga H, Suga K, Ide R, Shimizu A, Inoue A, Koike M. Examination of three-detector high-speed-rotation SPECT acquisition under breathhold in body: clinical application of 99mTc-MAA. Nippon Hoshasen Gijutsu Gakkai Zasshi. 2006;62(2):281–8.

    Article  Google Scholar 

  12. Harauz G, Bronskill MJ. Comparison of the liver’s respiratory motion in the supine and upright positions: concise communication. J Nucl Med. 1979;20(7):733–5.

    PubMed  CAS  Google Scholar 

  13. de Graaf W, Veteläinen RL, de Bruin K, van Vliet AK, van Gulik TM, Bennink RJ. 99mTc-GSA scintigraphy with SPECT for assessment of hepatic function and functional volume during liver regeneration in a rat model of partial hepatectomy. J Nucl Med. 2008;49(1):122–8.

    Article  PubMed  Google Scholar 

  14. Akaki S, Okumura Y, Sasai N, Sato S, Tsunoda M, Kuroda M, Kanazawa S, Hiraki Y. Hepatectomy simulation discrepancy between radionuclide receptor imaging and CT volumetry: influence of decreased unilateral portal venous flow. Ann Nucl Med. 2003;17(1):23–9.

    Article  PubMed  Google Scholar 

  15. Wakamatsu H, Nagamachi S, Kiyohara S, Fujita S, Kamimura K, Futami S, Nishii R, Nagano M, Kondou K, Kai M, Chijiiwa K, Tamura S. Predictive value of Tc-99m galactosyl human serum albumin liver SPECT on the assessment of functional recovery after partial hepatectomy: a comparison with CT volumetry. Ann Nucl Med. 2010;24(10):729–34.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors thank Prof. Junji Morishita from the Department of Health Sciences, School of Medicine, Kyushu University, for his valuable comments and suggestions aimed at improving the manuscript. We are also indebted to Mr. Steven Gardner for helpful advice during manuscript preparation. The authors wish to thank the Editorial Assistant of this journal for her initial and final polishing of the submitted manuscript which improved the overall readability and corrected the use of English expressions.

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Authors and Affiliations

  1. Department of Radiological Technology, Yamaguchi University Hospital, Yamaguchi, Japan

    Yasuyuki Ueda, Shohei Kudomi, Masahiro Koike, Yona Oishi, Hideyuki Iwanaga & Katsuhiko Ueda

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  1. Yasuyuki Ueda
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  2. Shohei Kudomi
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  3. Masahiro Koike
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  4. Yona Oishi
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  5. Hideyuki Iwanaga
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  6. Katsuhiko Ueda
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Correspondence to Yasuyuki Ueda.

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Ueda, Y., Kudomi, S., Koike, M. et al. Correction of liver displacement due to irregular respiration for SPECT images obtained using a multiple short-time acquisition with breath-holding technique. Radiol Phys Technol 5, 71–77 (2012). https://doi.org/10.1007/s12194-011-0138-x

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  • DOI: https://doi.org/10.1007/s12194-011-0138-x

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