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Bulk motion-independent analyses of water diffusion changes in the brain during the cardiac cycle

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An Erratum to this article was published on 24 February 2010

Abstract

We evaluated dynamic changes in water diffusion in the brain during the cardiac cycle by using cine diffusion MRI. On a 1.5-T MRI, ECG-triggered single-shot diffusion echo planar imaging was used with sensitivity encoding, halfscan, and rectangular field of view techniques for minimizing bulk motion effects such as brain pulsation, with a data-sampling window of 3 ms. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in the white matter zone were determined in ten healthy volunteers and then compared with the intracranial volume change (ICVC) revealed by phase-contrast cine MRI during the cardiac cycle. In addition, a frequency analysis of these waveforms was performed. ADC and FA values changed significantly during the cardiac cycle, despite minimizing the effect of bulk motion, i.e., independent of bulk motion. The ADC was synchronized with the ICVC during the cardiac cycle. A significant positive correlation was noted among their amplitudes. Analysis of the dynamic change of water diffusion by use of cine diffusion MRI facilitates the assessment of intracranial conditions.

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Acknowledgment

The author would like to thank the reviewers and the editorial assistants for the valuable comments and suggestions which significantly improved the presentation of this paper.

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Authors and Affiliations

  1. Department of Radiology, Tokai University Hachioji Hospital, 1838 Ishikawa, Hachioji, 192-0032, Japan

    Tomoya Nakamura

  2. Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan

    Tosiaki Miyati, Naoki Ohno & Katsuhiro Ichikawa

  3. Department of Radiology, Nagoya City University Hospital, 1 Kawasumi, Mizuho, Mizuho-ku, Nagoya, 467-8602, Japan

    Harumasa Kasai, Masato Yamada, Masaki Hara & Yuta Shibamoto

  4. Department of Neurosurgery and Restorative Neuroscience, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Mizuho-ku, Nagoya, 467-8601, Japan

    Mitsuhito Mase

  5. MR Clinical Science, Philips Medical Systems, 2-13-37 Kounan, Minato-ku, Tokyo, 108-8507, Japan

    Yuriko Suzuki

Authors
  1. Tomoya Nakamura
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  2. Tosiaki Miyati
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  3. Harumasa Kasai
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  4. Naoki Ohno
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  5. Masato Yamada
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  6. Mitsuhito Mase
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  7. Masaki Hara
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  8. Yuta Shibamoto
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  9. Yuriko Suzuki
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  10. Katsuhiro Ichikawa
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Corresponding author

Correspondence to Tomoya Nakamura.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s12194-010-0085-y

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Nakamura, T., Miyati, T., Kasai, H. et al. Bulk motion-independent analyses of water diffusion changes in the brain during the cardiac cycle. Radiol Phys Technol 2, 133–137 (2009). https://doi.org/10.1007/s12194-009-0056-3

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  • DOI: https://doi.org/10.1007/s12194-009-0056-3

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