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Increased circulating heat shock protein 70 (HSPA1A) levels in gestational diabetes mellitus: a pilot study

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Cell Stress and Chaperones Aims and scope

Abstract

Recent data indicate that serum Hsp70 (HSPA1A) levels are increased in type 1 and 2 diabetes mellitus. However, there is no report in the literature on circulating Hsp70 levels in gestational diabetes mellitus. In this pilot study, we measured serum Hsp70 levels in 11 pregnant women with pregestational diabetes, 38 women with gestational diabetes, and 40 healthy pregnant women with ELISA. Plasma glucose levels, serum insulin concentrations, HbA1c values, and the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) index were also determined. According to our results, serum Hsp70 concentrations were significantly higher in women with pregestational and gestational diabetes mellitus than in healthy pregnant women. In addition, pregestational diabetic women had significantly higher Hsp70 levels than those with gestational diabetes. Furthermore, in the group of women with gestational diabetes mellitus, serum Hsp70 levels showed a significant positive correlation with HbA1c values. However, there was no other relationship between clinical features and metabolic parameters of the study subjects and their serum Hsp70 levels in either study group. In conclusion, we demonstrated for the first time in the literature that serum Hsp70 levels are increased and correlate with HbA1c values in women with gestational diabetes mellitus. Nevertheless, further studies are needed to determine whether circulating Hsp70 plays a causative role in the pathogenesis of gestational diabetes or elevated serum Hsp70 levels are only consequences of the disease.

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Acknowledgments

The skillful technical assistance of Szigeti Antalné is acknowledged with many thanks. This work was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences, as well as by a research grant from the Hungarian Scientific Research Fund (PD 109094).

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Authors and Affiliations

  1. First Department of Obstetrics and Gynecology, Semmelweis University, Baross utca 27, Budapest, 1088, Hungary

    Zoltán Garamvölgyi, János Rigó Jr, András Kecskeméti & Attila Molvarec

  2. Third Department of Internal Medicine, Semmelweis University, Budapest, Hungary

    Zoltán Prohászka

  3. Research Group of Inflammation Biology and Immunogenomics, Hungarian Academy of Sciences, Budapest, Hungary

    Zoltán Prohászka

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  1. Zoltán Garamvölgyi
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  2. Zoltán Prohászka
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  3. János Rigó Jr
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  4. András Kecskeméti
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  5. Attila Molvarec
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Correspondence to Attila Molvarec.

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Garamvölgyi, Z., Prohászka, Z., Rigó, J. et al. Increased circulating heat shock protein 70 (HSPA1A) levels in gestational diabetes mellitus: a pilot study. Cell Stress and Chaperones 20, 575–581 (2015). https://doi.org/10.1007/s12192-015-0579-y

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  • DOI: https://doi.org/10.1007/s12192-015-0579-y

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