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References
Bickler SW (2000) Non-communicable diseases: is their emergence in industrialized societies related to changes in neuroendocrine function? Med Hypotheses 54:825–858
Bickler SW (2006) Tropical enteropathy protects against Western diseases in environments of poor sanitation. Med Hypotheses 67:146–150
Bickler SW, De Maio A (2008) Western diseases: current concepts and implications for pediatric surgery research and practice. Pediatr Surg Int 24:251–255
Bowen ETW, Lloyd G, Harris WJ, Platt GS, Baskerville A, Vella EE (1977) Viral haemorrhagic fever in Southern Sudan and Northern Zaire. Lancet 1:571–573
Carette JE, Raaben M, Wong AC et al (2011) Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature 477:340–343
Chan M (2014) “WHO Director-General addresses UN security council on Ebola.” World Health Organization, September 18, 2014. http://www.who.int/dg/speeches/2014/security-council-ebola/en/. Accessed 28 Oct 2014
Chowell G, Nishiura H (2014) Transmission dynamics and control of Ebola virus disease (EVD): a review. BMC Med 12:196
Coté M, Misasi J, Ren T et al (2011) Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection. Nature 477:344–348
Fedson DS (2014) How will physicians respond to the next influenza pandemic? Clin Infect Dis 58:233–237
Frey T, De Maio A (2007) Increased expression of CD14 in macrophages after inhibition of the cholesterol biosynthetic pathway by lovastatin. Mol Med 13:592–604
Frey T, De Maio A (2009) The antifungal agent itraconazole induces the accumulation of high mannos glycoproteins in macrophages. J Biol Chem 284:16882–16890
Idaghdour Y, Storey JD, Jadallah SJ, Gibson G (2008) A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs. PLoS Genet 4:e1000052
Johnson KM, Webb PA, Lange JV, Murphy FA (1977) A new virus causing acute haemorrhagic fever in Zaire. Lancet 1:569–571
Kohjima M, Enjoji M, Yoshimoto T et al (2013) Add-on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C. J Med Virol 85:250–260
Krishnan A, Miller EH, Herbert AS et al (2012) Niemann-Pick C1 (NPC1)/NPC1-like1 chimeras define sequences critical for NPC1’s function as a filovirus entry receptor. Viruses 4:2471–2484
Mañes S, del Real G, Martinez AC (2003) Pathogens: raft hijackers. Nat Rev 3:557–568
Martines RB, Ng DL, Greer PW, Rollin PE, Zaki SR (2014) Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses. J Pathol. doi:10.1002/path.4456
Miller EH, Chandran K (2012) Filovirus entry into cells—new insights. Curr Opin Virol 2:206–214
Nath AP, Arafat D, Gibson G (2012) Using blood informative transcripts in geographical genomics: impact of lifestyle on gene expression in Fijians. Front Genet 3:243
Ng M, Ndungo E, Jangra RK et al (2014) Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1. Virology 468-470C:637–646
Niño DF, Cauvi DM, De Maio A (2014) Itraconazole, a commonly used antifungal, inhibits Fcγ receptor-mediated phagocystosis: alteration of Fcγ receptor glycosylation and gene expression. Shock 42:52–59
Rosenbaum AI, Maxfield FR (2011) Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches. J Neurochem 116:789–795
Shoemaker CJ, Chornberg KL, Delos SE et al (2013) Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One 8:e56265
Vasunilashorn S, Crimmins EM, Kim JKI et al (2010) Blood lipids, infection, and inflammatory markers in the Tsimane of Bolivia. Am J Hum Biol 22:731–740
WHO (2014a) October 25 Ebola Response Roadmap. World Health Organization. http://apps.who.int/iris/bitstream/10665/137185/1/roadmapupdate25Oct14_eng.pdf?ua=1. Accessed October 28, 2014
WHO (2014b) Ebola Response Roadmap. World Health Organization. http://apps.who.int/iris/bitstream/10665/131596/1/EbolaResponseRoadmap.pdf?ua=1&ua=1. Accessed October 28, 2014
WHO Ebola Response Team (2014) Ebola virus disease in West Africa—first 9 months of the epidemic and forward projections. N Engl J Med 371:1481–1495
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This work was supported by the National Institutes of General Medical Sciences (GM R01 098455) and Fogarty International Center (R24TW008910).
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Bickler, S.W., Lizardo, R.E. & De Maio, A. The transition from a rural to an urban environment alters expression of the human Ebola virus receptor Neiman-Pick C1: implications for the current epidemic in West Africa. Cell Stress and Chaperones 20, 203–206 (2015). https://doi.org/10.1007/s12192-014-0557-9
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DOI: https://doi.org/10.1007/s12192-014-0557-9