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Serum heat shock protein 27 levels in patients with hepatocellular carcinoma

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Cell Stress and Chaperones Aims and scope

Abstract

Levels of serum heat shock protein 27 (sHsp27) have been studied in numerous cancer types, but their potential relevance in patients with hepatocellular carcinoma (HCC) is undetermined. Our aim was to compare sHsp27 levels in patients with HCC and HCC-free controls. Specifically, we recruited 71 patients with HCC (80 % with early tumour), 80 patients with chronic liver disease (59 with liver cirrhosis and 21 with chronic active hepatitis) and 42 healthy subjects. sHsp27 was measured by immunoenzymatic assay. Results showed that sHsp27 levels were significantly (p < 0.001) higher in patients with HCC than in the other groups, particularly in those with hepatitis C virus (HCV)-related disease. In HCC patients, sHsp27 levels were not associated with prognostic risk factors, such as size/multiplicity of nodules and stage. In logistic regression analysis, performed in patients with liver disease, log-sHsp27 was associated with a significant age-adjusted 2.5-fold increased odds ratio of HCC and with a significant 4.4-fold higher odds ratio of HCC in the subgroup with HCV-related liver disease. In receiver operating characteristic curve analysis, sensitivity and specificity of the best sHsp27 cut-off value (456.5 pg/ml) for differentiating patients with HCC from those with HCC-free chronic liver disease were 70 and 73 %, respectively. In conclusion, sHsp27 levels are enhanced in patients with HCC and may represent a candidate biomarker of HCC.

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Acknowledgments

This study received grant supports from Piedmont Region “Applied Scientific Research” CIPE and University of Turin.

Conflict of interest

The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy

    Gabriella Gruden, Valentina Lolli, Loretta Cosso, Erika Dellavalle, Silvia Pinach, Graziella Bruno, Mario Rizzetto & Paolo Cavallo Perin

  2. Department of Gastro-Hepatology, S. Giovanni Battista Molinette Hospital, Turin, Italy

    Patrizia Carucci, Emanuela Rolle, Alessandro Cantamessa, Maria Lorena Abate & Franco Brunello

  3. Department of Surgery, S. Giovanni Battista Molinette Hospital, Turin, Italy

    Donata Campra

Authors
  1. Gabriella Gruden
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  2. Patrizia Carucci
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  3. Valentina Lolli
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  4. Loretta Cosso
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  5. Erika Dellavalle
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  6. Emanuela Rolle
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  7. Alessandro Cantamessa
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  8. Silvia Pinach
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  9. Maria Lorena Abate
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  10. Donata Campra
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  11. Franco Brunello
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  12. Graziella Bruno
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  13. Mario Rizzetto
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  14. Paolo Cavallo Perin
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Correspondence to Gabriella Gruden.

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Gruden, G., Carucci, P., Lolli, V. et al. Serum heat shock protein 27 levels in patients with hepatocellular carcinoma. Cell Stress and Chaperones 18, 235–241 (2013). https://doi.org/10.1007/s12192-012-0377-8

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  • DOI: https://doi.org/10.1007/s12192-012-0377-8

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