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Xenohormesis: health benefits from an eon of plant stress response evolution

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Cell Stress and Chaperones Aims and scope

Abstract

Xenohormesis is a biological principle that explains how environmentally stressed plants produce bioactive compounds that can confer stress resistance and survival benefits to animals that consume them. Animals can piggyback off products of plants' sophisticated stress response which has evolved as a result of their stationary lifestyle. Factors eliciting the plant stress response can judiciously be employed to maximize yield of health-promoting plant compounds. The xenohormetic plant compounds can, when ingested, improve longevity and fitness by activating the animal's cellular stress response and can be applied in drug discovery, drug production, and nutritional enhancement of diet.

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Acknowledgements

The authors thank Ben Sherwood of the Linnean Society library for references and David Campbell, Jeff Leung, and Konrad Howitz for helpful feedback.

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Authors and Affiliations

  1. Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Denver, School of Medicine, Aurora, CO, USA

    Philip L. Hooper

  2. Department of Anthropology and Program in Interdisciplinary Biological and Biomedical Sciences, University of New Mexico, Albuquerque, NM, USA

    Paul L. Hooper

  3. Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Michael Tytell

  4. Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

    Lászlo Vígh

  5. P.O. Box 245, Glen Haven, CO, 80532, USA

    Philip L. Hooper

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  1. Philip L. Hooper
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  2. Paul L. Hooper
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  4. Lászlo Vígh
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Correspondence to Philip L. Hooper.

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Hooper, P.L., Hooper, P.L., Tytell, M. et al. Xenohormesis: health benefits from an eon of plant stress response evolution. Cell Stress and Chaperones 15, 761–770 (2010). https://doi.org/10.1007/s12192-010-0206-x

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  • DOI: https://doi.org/10.1007/s12192-010-0206-x

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