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The small heat shock protein, HSPB6, in muscle function and disease

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Cell Stress and Chaperones Aims and scope

Abstract

The small heat shock protein, HSPB6, is a 17-kDa protein that belongs to the small heat shock protein family. HSPB6 was identified in the mid-1990s when it was recognized as a by-product of the purification of HSPB1 and HSPB5. HSPB6 is highly and constitutively expressed in smooth, cardiac, and skeletal muscle and plays a role in muscle function. This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of action; and therapeutic implications.

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Acknowledgements

This work was supported by National Institute of Health RO1HL58027 and RO1HL70715 and a Veterans Administration Merit Review award to C.M. Brophy.

Disclosures

The patents for the HSPB6 phosphopeptide are owned by Arizona State University and the Veteran's Administration. The intellectual property has been licensed to Capstone Therapeutics, Tempe, AZ, USA and the authors (C.D., P.K., E.F., C.F., M.S., and C.M.B.) have financial interest in this technology.

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Authors and Affiliations

  1. Capstone Therapeutics, 1275 West Washington Street, Suite 101, Tempe, AZ, 85281, USA

    Catherine M. Dreiza & Michael R. Sheller

  2. Department of Veterans Affairs Medical Center, Vanderbilt University Medical Center, Nashville, TN, USA

    Padmini Komalavilas & Colleen M. Brophy

  3. Center for Metabolic Biology, Arizona State University, Tempe, AZ, USA

    Padmini Komalavilas, Elizabeth J. Furnish, Christopher C. Smoke & Colleen M. Brophy

  4. Vanderbilt University Medical Center, Nashville, TN, USA

    Charles R. Flynn

  5. Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY, USA

    Luciana B. Lopes

Authors
  1. Catherine M. Dreiza
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  2. Padmini Komalavilas
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  3. Elizabeth J. Furnish
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  4. Charles R. Flynn
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  5. Michael R. Sheller
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  6. Christopher C. Smoke
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  7. Luciana B. Lopes
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  8. Colleen M. Brophy
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Correspondence to Catherine M. Dreiza.

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Dreiza, C.M., Komalavilas, P., Furnish, E.J. et al. The small heat shock protein, HSPB6, in muscle function and disease. Cell Stress and Chaperones 15, 1–11 (2010). https://doi.org/10.1007/s12192-009-0127-8

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