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The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells

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Cell Stress and Chaperones Aims and scope

Abstract

Evidence that membrane-bound and extracellular heat shock proteins (HSPs) with molecular weights of 70 and 90 kDa are potent stimulators of the immune responses has accumulated over the last decade. In this review, we discuss the modulation of Hsp70 expression, a major stress-inducible member of the HSP70 family, in the cytoplasm and on the plasma membrane of tumor cells by clinically applied interventions such as radio- and chemotherapy.

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Abbreviations

13-RA:

13-cis-retinoic acid

ALL:

acute lymphoid leukemia

AML:

acute myeloid leukemia

APC(s):

antigen presenting cell(s)

APL:

acute promyelocytic leukemia

ARA-CTP:

arabinosyl-cytosin-triphosphate

ASA:

acetyl-salicylic acid

ATRA:

all-trans-retinoic acid

B-CLL:

B cell chronic lymphoid leukemia

CD:

cluster of differentiation (nomenclature for surface proteins of human leucocytes)

CLX:

celecoxib

COX:

cyclooxygenase

ER:

endoplasmic reticulum

Hsp:

heat shock protein

IL:

interleukin

NCR:

natural cytotoxicity receptor

NHL:

non-Hodgkin lymphoma

NK:

natural killer cell

NKG2D:

C-type lectin-like immunoreceptor on NK cells

NKT cells:

natural killer-like T cells

PI3K:

phosphatidyl-inositol-3-phosphat kinase

PIO:

pioglitazone

PIPLC:

phosphatidyl-inositol-specific phospholipase C

PKC:

protein kinase C

RFX:

rofecoxib

SBU:

sodium butyrate

TKD:

14-mer Hsp70 peptide with the amino acid sequence T-K-D-N-N-L-L-G-R-F-E-L-S-G

TLR:

Toll-like receptor

TNF:

tumor necrosis factor

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Acknowledgment

This work was supported in part by the EU-Transnet project MRTN-2004-512253, the DFG project MU1238 7/2, and the multimmune GmbH, Munich. We want to thank Prof. Graham Pockley (University of Sheffield, UK, presently Technical University Munich) for constructive suggestions and for proofreading of the manuscript.

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  1. Department of Radiotherapy and Radiooncology and Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)–Institute of Pathology, Clinical Cooperation Group “Innate Immunity in Tumor Biology”, University Hospital rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675, Munich, Germany

    Mathias Gehrmann, Michael Molls & Gabriele Multhoff

  2. Institute of Medical Biochemistry and Molecular Biology, University of Greifswald, Clinical Center, Ferdinand-Sauerbruch-Strasse, 17487, Greifswald, Germany

    Jürgen Radons

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  1. Mathias Gehrmann
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Correspondence to Gabriele Multhoff.

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Gehrmann, M., Radons, J., Molls, M. et al. The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells. Cell Stress and Chaperones 13, 1–10 (2008). https://doi.org/10.1007/s12192-007-0006-0

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