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Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia

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Abstract

Myeloid-derived suppressor cells (MDSCs) are thought to help provide a cellular microenvironments in many solid tumors, in which transformed cells proliferate, acquire new mutations, and evade host immunosurveillance. In the present study, we found that MDSCs (CD33 + CD11b + HLA-DRlow/neg) in bone marrow were significantly increased in adult acute myeloid leukemia (AML) patients. MDSCs levels in newly diagnosed AML patients correlated well with extramedullary infiltration and plasma D-dimer levels. Remission rates in the MDSCs > 1500 group and MDSCs < 1500 group were 72.73 and 81.25 %, respectively. No significant differences were found between the two groups. MDSC levels in the complete remission group were significantly decreased after chemotherapy, while in the partial remission and non-remission groups, there were no significant differences. The level of MDSCs in the high minimal residual disease (MRD) group was significantly higher than that in the middle and low MRD groups. High levels of Wilms’ Tumor-1 (WT-1) protein were strongly correlated with higher bone marrow MDSC levels. In conclusion, we report here a population of immunosuppressive monocytes in the bone marrow of patients with AML characterized by the CD33highCD11b + HLA-DRlow/neg phenotype. These cells appear to impact the clinical course and prognosis of AML. This data may provide potentially important targets for novel therapies.

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Acknowledgments

This study was supported by grants from the National Natural Science Foundation of China (No. 81200575 and No. 81000731), the Promotive Research Fund for Excellent Young and Middle-Aged Scientists of Shandong Province (No. BS2012YY025) and the Shandong Provincial Key Clinical specialist construction projects (Lu Wei Yi [2013] 26).

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Authors and Affiliations

  1. Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People’s Republic of China

    Hui Sun, Zhi-fen Zhang, Ying Ju, Li Li & Bing-chang Zhang

  2. Department of Bone Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People’s Republic of China

    Yi Li

  3. Department of Center Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People’s Republic of China

    Bin Liu

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  1. Hui Sun
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  2. Yi Li
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  3. Zhi-fen Zhang
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  4. Ying Ju
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  5. Li Li
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  6. Bing-chang Zhang
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  7. Bin Liu
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Correspondence to Bin Liu.

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Sun, H., Li, Y., Zhang, Zf. et al. Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia. Int J Hematol 102, 579–586 (2015). https://doi.org/10.1007/s12185-015-1865-2

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  • DOI: https://doi.org/10.1007/s12185-015-1865-2

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