Abstract
To examine the late effects and health-related quality of life among childhood cancer survivors (CCS) after stem cell transplantation (SCT), we performed a cross-sectional survey using self-rating questionnaires. The subjects were divided into 3 groups: SCT-treated CCS, CCS treated without SCT, and the general population who matched for age, gender, residential area, and work status with the CCS. We analyzed the questionnaires of 185 CCS and 1,000 control participants. The median ages of CCS at diagnosis and survey were 8 and 22 years, respectively. The mean final heights of male and female participants were significantly lower for SCT-treated CCS than for CCS treated without SCT and the controls. Among the SCT-treated CCS, >40% were underweight (BMI < 18.5). Late effects were observed in 78% of SCT-treated CCS versus 45% of CCS treated without SCT. Multivariate analysis revealed that >15 years’ duration after therapy completion (OR 2.95; p = 0.014), solid tumors (4.31; p = 0.040), radiotherapy (2.82; p = 0.009), recurrence (4.22; p = 0.017), and SCT (3.39; p = 0.014) were significant risk factors for late effects. Subjective symptoms were significantly frequent in SCT-treated CCS. Physical dysfunction, psychological stress, and social adaptation problems were observed in >70% of SCT-treated CCS.
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Acknowledgments
The institutions that provided patient data and enabled recruitment of CCS in the survey are listed in Appendix 1. This study was supported by research grants from the Japanese Ministry of Health, Labor and Welfare (Grant No. 18-14: “Study of quality of life and prognosis in childhood cancer survivors and establishment of the long-term follow-up system”).
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Appendices
Appendix 1
See Table 7.
Appendix 2
Hearing impairment, tinnitus, vertigo, vision acuity, cataract, glaucoma, diplopia, dry eye, smell abnormality, urinary tract infection, urolithiasis, renal failure, urinary examination abnormality, hypothyroidism, hyperthyroidism, goiter, diabetes mellitus, growth hormone deficiency, growth hormone replacement, osteoporosis, delayed puberty, precocious puberty, suspected infertility, examination for infertility, menarche, irregular menstruation, pill usage, semen problems, any heart disease, arrhythmia, heart failure, angina, myocardial infarction, hypertension, stroke, valvular heart disease, thrombosis, heart failure during pregnancy, chronic bronchitis, bronchial asthma, recurrent tonsillitis, pulmonary emphysema, pulmonary fibrosis, other lung disease, gallstone, hepatitis, jaundice, liver cirrhosis, peptic ulcer, any intestinal disease, chronic diarrhea, chronic constipation, any tooth disease, scoliosis, any other spine disease, extremity dysfunction, limb length discrepancy, joints problems, cerebral palsy, paralysis, developmental delay, epilepsy, headache, faintness/tremor, muscle weakness, chronic pain, sensory disturbance, dysphagia, other neurological disorders, skin problems, alopecia, and any allergic disease.
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Ishida, Y., Honda, M., Ozono, S. et al. Late effects and quality of life of childhood cancer survivors: Part 1. Impact of stem cell transplantation. Int J Hematol 91, 865–876 (2010). https://doi.org/10.1007/s12185-010-0584-y
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DOI: https://doi.org/10.1007/s12185-010-0584-y