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Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation

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Abstract

Matrix metalloproteinases (MMPs) have been implicated in a variety of normal and pathological conditions that involve matrix degradation and remodelling. We investigated the role of MMPs in acute graft-versus-host disease (aGVHD) in 29 patients who had undergone allogeneic haematopoietic stem cell transplantation. The present study showed that the serum levels of MMP-9, but not those of MMP-2, significantly correlated with the occurrence and severity of aGVHD. Moreover, immunohistochemical analysis of the cutaneous lesions of patients with aGVHD revealed an increased number of inflammatory cells positive for MMP-9. These results suggest that MMP-9 might play an important role in the pathogenesis of aGVHD.

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Authors and Affiliations

  1. Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan

    Kozo Tagami, Toshiaki Yujiri, Toru Takahashi, Nobuaki Kizuki, Yoshinori Tanaka, Noriyuki Mitani, Yukinori Nakamura, Koichi Ariyoshi, Toshihiko Ando & Yukio Tanizawa

  2. First Department of Pathology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan

    Toshikazu Gondo

  3. Third Department of Internal Medicine, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan

    Toshiaki Yujiri

Authors
  1. Kozo Tagami
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  2. Toshiaki Yujiri
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  3. Toru Takahashi
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  4. Nobuaki Kizuki
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  5. Yoshinori Tanaka
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  6. Noriyuki Mitani
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  7. Yukinori Nakamura
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  8. Koichi Ariyoshi
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  9. Toshihiko Ando
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  10. Toshikazu Gondo
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  11. Yukio Tanizawa
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Correspondence to Toshiaki Yujiri.

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Tagami, K., Yujiri, T., Takahashi, T. et al. Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation. Int J Hematol 90, 248–252 (2009). https://doi.org/10.1007/s12185-009-0358-6

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  • DOI: https://doi.org/10.1007/s12185-009-0358-6

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