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A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China

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Abstract

The frequency of subtypes of lymphoid neoplasms was determined in a prospective series of 831 patients presenting at 29 Shanghai hospitals over a 4-year period. Diagnosis and classification was established in a single laboratory according to the 2001 WHO classification system. The frequency of non-Hodgkin lymphoma was 87.6% (n = 728) and Hodgkin lymphoma was 12.4% (n = 103). The most prevalent NHL subtypes diagnosed using WHO criteria were diffuse large B cell lymphoma (DLBCL), precursor B lymphoblastic leukemia/lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Although a low incidence has been reported in some Asian populations, CLL/SLL was commonly encountered, indicating that chronic lymphoid neoplasms are not rare in Shanghai. Consistent with previous reports, our findings indicate a decrease in the frequency of follicular lymphoma and an increase in T cell neoplasms compared to the West. Precursor T lymphoblastic leukemia/lymphoma, anaplastic large T cell lymphoma, aggressive NK cell leukemia, angioimmunoblastic T cell lymphoma and peripheral T cell lymphoma were prominent subtypes of T cell NHL.

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Acknowledgments

We would like to extend our appreciation to Ann Louden for manuscript and clerical assistance and Allan Holsomback for database management. We would also like to thank the participating hospitals including Cancer Hospital, Huashan Hospital, Xinhua Hospital, Long March Hospital, Huang Pu Central District Hospital, Renji Hospital, Ruijin Hospital, Huadong Hospital, Jin An Central Hospital, No. 1 People’s Hospital, No. 5 People’s Hospital, No. 6 People’s Hospital, No. 9 People’s Hospital, Yang Pu Central Hospital, Zha Bei Central Hospital, Shu Guang Hospital, Chang Ning Central Hospital, Tong Ji Hospital, Shong Jin Central Hospital, Zhong Shan Hospital, Railway Hospital, Rong Hua Hospital, Changhai Hospital, Occupational Disease Hospital, Jiading Central Hospital, 455 Hospital, Shidong Hospital, No. 1 Baoshan Hospital, and Putuo Central Hospital.

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Author notes

  1. Sherilyn A. Gross

    Present address: Fudan-Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, 130 Dong An Road, 200032, Shanghai, China

Authors and Affiliations

  1. Fudan-Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, 130 Dong An Road, 200032, Shanghai, China

    Liming Bao, Yan Chen, Xiao Qin Wang & Richard D. Irons

  2. Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Denver, Denver, CO, USA

    Sherilyn A. Gross, Anh Le & Richard D. Irons

  3. Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China

    Xiongzeng Zhu

  4. Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Liming Bao

  5. Department of Pathology, School of Medicine, University of Colorado Denver, Denver, CO, USA

    John Ryder & Richard D. Irons

  6. Cinpathogen, Inc., Boulder, CO, USA

    Richard D. Irons

  7. Cinpathogen, Inc., Shanghai, China

    Richard D. Irons

Authors
  1. Sherilyn A. Gross
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  2. Xiongzeng Zhu
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  3. Liming Bao
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  4. John Ryder
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  5. Anh Le
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  6. Yan Chen
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  7. Xiao Qin Wang
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  8. Richard D. Irons
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Correspondence to Richard D. Irons.

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Gross, S.A., Zhu, X., Bao, L. et al. A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China. Int J Hematol 88, 165–173 (2008). https://doi.org/10.1007/s12185-008-0132-1

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  • DOI: https://doi.org/10.1007/s12185-008-0132-1

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