Abstract
Two novel complementary analytical methods, namely an extraction-free capillary electrophoresis coupled to mass spectrometry (CE-MS) and direct immersion-solid-phase microextraction combined with gas chromatography-mass spectrometry (DI-SPME-GC-MS), have been developed and successfully applied for the determination of biogenic amines (BAs) in wine and fruit wine. They have been rigorously compared to each other in terms of various analytical criteria, and in addition, their “greenness,” standing for general safety and eco-friendliness, has been assessed using three different tools. Both procedures established in this work allow to determine the major BAs that are important for human health and life. Due to a faster and easier sample preparation step, the CE-MS method seems to be more user-friendly for routine and laborious analyses. On the other hand, the LOD values noted for the GC-MS method were always lower than those for the CE-MS approach. The lowest LOD in GC-MS was 3.1 ng/mL, while in CE-MS 25 ng/mL. This may be beneficial when BAs are present in wine at low concentration. The recovery values obtained for the CE-MS and GC-MS methods were similar and ranged from 65 to 117% and 64 to 106%, respectively. The greenness profile of these methodologies has been assessed and compared to each other using the following tools: National Environmental Methods Index (NEMI), greening profile algorithm, and analytical Eco-Scale. The evaluation based on all three scales indicates that both methods proposed in this works meet the requirements of a “green analytical chemistry” and can be safely used for the routine analysis of the studied BAs in wine samples with a minimal detrimental impact on human health and the environment.
Similar content being viewed by others
References
Ancín-Azpilicueta C, González-Marco A, Jiménez-Moreno N (2008) Current knowledge about the presence of amines in wine. Crit Rev Food Sci 48:257–275
Bardócz S (1995) Polyamines in food and their consequences for food quality and human health. Trends Food Sci Technol 6:341–346
Cunha SC, Faria MA, Fernandes JO (2011) Gas chromatography–mass spectrometry assessment of amines in port wine and grape juice after fast chloroformate extraction/derivatization. J Agric Food Chem 59:8742–8753
Erim FB (2013) Recent analytical approaches to the analysis of biogenic amines in food samples. Trends Anal Chem 52:239–247
Gałuszka A, Migaszewski ZM, Konieczka P, Namieśnik J (2012) Analytical Eco-Scale for assessing the greenness of analytical procedures. TRAC Trend Anal Chem 37:61–72
Ginterová P, Marák J, Staňová A, Maier V, Sevčík J, Kaniansky D (2012) Determination of selected biogenic amines in red wines by automated on-line combination of capillary isotachophoresis–capillary zone electrophoresis. J Chromatogr B 904:135–139
Jansen SC, van Dusseldorp M, Bottema KC, Dubois AEJ (2003) Intolerance to dietary biogenic amines: a review. Ann Allergy Asthma Immunol 91:233–241
Lehtonen P (1996) Determination of amines and amino acids in wine—a review. Am J Enol Vit 47:127–133
Manetta AC, Di Giuseppe L, Tofalo R, Martuscelli M, Schirone M, Giammarco M, Suzzi G (2016) Evaluation of biogenic amines in wine: determination by an improved HPLC-PDA method. Food Control 62:351–356
Miranda A, Leça JM, Pereira V, Marques JC (2017) Analytical methodologies for the determination of biogenic amines in wines: an overview of the recent trends. J Anal Bioanal Sep Tech 2:1–6
Mohammed GI, Bashammakh AS, Alsibaai AA, Alwael H, El-Shahawi MS (2016) A critical overview on the chemistry, clean-up and recent advances in analysis of biogenic amines in foodstuffs. Trends Anal Chem 78:84–94
Nalazek-Rudnicka K, Wasik A (2017) Development and validation of an LC–MS/MS method for the determination of biogenic amines in wines and beers. Monatsh Chem 148:1685–1696
Nowak P, Woźniakiewicz M, Mitoraj MP, Garnysz M, Kościelniak P (2015) Modulation of pKa by cyclodextrins; subtle structural changes induce spectacularly different behaviors. RSC Adv 5:77545–77552
Önal A (2007) A review: current analytical methods for the determination of biogenic amines in food. Food Chem 103:1475–1486
Papageorgiou M, Lambropoulou D, Morrison C, Kłodzińska E, Namieśnik J, Płotka-Wasylka J (2018) Literature update of analytical methods for biogenic amines determination in food and beverages. Trends Anal Chem 98:128–142
Płotka-Wasylka JM, Morrison C, Biziuk M, Namieśnik J (2015) Chemical derivatization processes applied to amine determination in samples of different matrix composition. Chem Rev 115:4693–4718
Płotka-Wasylka J, Simeonov V, Namieśnik J (2016) An in situ derivatization–dispersive liquid-liquid microextraction combined with gas-chromatography–mass spectrometry for determining biogenic amines in home-made fermented alcoholic drinks. J Chromatogr A 1453:10–18
Pozo-Bayón MA, Monagas M, Bartolomé B, Moreno-Arribas MV (2012) Wine features related to safety and consumer health: an integrated perspective. Crit Rev Food Sci Nutr 52:31–54
Proestos C, Loukatos P, Komaitis M (2008) Determination of biogenic amines in wines by HPLC with precolumn dansylation and fluorimetric detection. Food Chem 106:1218–1224
Raynie D, Driver J (2009) Green Assessment of Chemical Methods. In: 13th Annual Green Chemistry and Engineering Conference, Maryland
Santos MHS (1996) Biogenic amines: their importance in foods. Int J Food Microbiol 29:213–231
Sigma-Aldrich (2013) Solid Phase Microextraction Fiber Assemblies. Available at: https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/General_Information/1/t794123.pdf (available on 5–12-2017)
Simon-Sarkadi L, Gelencsér É, Vida A (2003) Immunoassay method for detection of histamine in foods. Acta Aliment Hung 32:89–93
Stadnik J, Dolatowski ZJ (2010) Biogenic amines in meat and fermented meat products. Acta Sci Pol Technol Aliment 9:251–263
Standarová E, Borkovcová I, Vorlová L (2008) The occurrence of biogenic amines in dairy products on the Czech market. Acta Sci Pol Med Vet 7:35–42
Funding
This study was funded by the Polish Ministry of Science and Higher Education within the “Iuventus Plus” program in years 2015–2018, project no. IP2014 037573. The study was carried out with equipment purchased thanks to the European Regional Development Fund within framework of the Polish Innovation Economy Operational Program (contract no. POIG.0 2.01.00-12-0 23/08).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Justyna Płotka-Wasylka has received research grants from the Polish Ministry of Science and Higher Education and she declares no conflict of interest. Michał Woźniakiewicz declares that he has no conflict of interest. Aneta Woźniakiewicz declares that she has no conflict of interest. Paweł Mateusz Nowak declares that he has no conflict of interest. Ewa Kłodzińska declares that she has no conflict of interest. Jacek Namieśnik declares that he has no conflict of interest.
Ethical Approval
This article does not contain any studies with human participants or animals performed by any of the authors.
Informed Consent
Not applicable.
Rights and permissions
About this article
Cite this article
Woźniakiewicz, M., Woźniakiewicz, A., Nowak, P.M. et al. CE-MS and GC-MS as “Green” and Complementary Methods for the Analysis of Biogenic Amines in Wine. Food Anal. Methods 11, 2614–2627 (2018). https://doi.org/10.1007/s12161-018-1219-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12161-018-1219-9