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Carbon-Nanotube-Based Sensor for the Determination of Butylated Hydroxyanisole in Food Samples

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Abstract

The electrochemical oxidation of butylated hydroxyanisole (BHA), a synthetic phenolic antioxidant, has been studied by differential pulse voltammetry (DPV) at multiwalled carbon nanotube (MWCNT)-modified platinum sensor in 0.1 M phosphate buffer (pH 4) as supporting electrolyte. The developed sensor showed catalytic activity and stability for BHA oxidation. Linear calibration graph was obtained in the concentration range of 1 × 10−6–1 × 10−7 M, and the detection limit was 9.49 × 10−8 M. Effect of common interfering ions have been investigated in simulated mixtures containing high levels of interfering ions, and the sensor was found to be tolerant against these ions. This method has been proved to be effective and successfully applied for the determination of BHA in commercially available vegetable oil and mayonnaise samples, providing a promising and convenient method to monitor the superscale use of phenolic antioxidant.

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References

  • Adams RN (1969) Electrochemistry at solid electrodes. Marcel-Dekker, New York

    Google Scholar 

  • Agui ML, Reviejo AJ, Yanez-Sedeno P, Pingarron JM (1995) Analytical applications of cylindrical carbon fiber microelectrodes. Simultaneous voltammetric determination of phenolic antioxidants in food. Anal Chem 67:2195–2200

    Article  CAS  Google Scholar 

  • Capitan-Vallvey LF, Valencia MC, Nicolas EA (2004) Solid-phase ultraviolet absorbance spectrophotometric multisensor for the simultaneous determination of butylated hydroxytoluene and co-existing antioxidants. Anal Chim Acta 503:179–186

    Article  CAS  Google Scholar 

  • Ceballos CD, Zón MA, Fernández H (2006) Using square wave voltammetry on ultramicroelectrodes to determine synthetic antioxidants in vegetable oils. J Chem Educ 83:1349–1352

    Article  CAS  Google Scholar 

  • De la Fuente C, Acuna JA, Vazquez MD, Tascon LM, Gomez MI, Sanchez Batanero P (1997) Preparation of a polypyrrole electrode modified with a nickel phthalocyanine complex. Application to the determination of an antioxidant (propylgallate) in foods. Talanta 44:685–695

    Article  Google Scholar 

  • De la Fuente C, Acuna JA, Vazquez MD, Tascon LM, Batanero PS (1999) Voltammetric determination of the phenolic antioxidants 3-tert-butyl-4-hydroxyanisole and tert-butylhydroquinone at a polypyrrole electrode modified with a nickel phthalocyanine complex. Talanta 49:441–452

    Article  Google Scholar 

  • Delgado-Zamarreno MM, Gonzalez-Maza I, Sanchez-Perez A, Martinez RC (2007) Analysis of synthetic phenolic antioxidants in edible oils by micellar electrokinetic capillary chromatography. Food Chem 100:1722–1727

    Article  CAS  Google Scholar 

  • Garcia CD, Ortiz PI (1998) Determination of tert-butylhydroxytoluene by flow injection analysis at polymer modified glassy carbon electrodes. Electroanalysis 10:832–835

    Article  CAS  Google Scholar 

  • Gatrell M, Kirk DW (1990) The electrochemical oxidation of aqueous phenol at a glassy carbon electrode. Can J Chem Eng 68:997–1003

    Article  Google Scholar 

  • Gatrell M, Kirk DW (1993) A study of electrode passivation during aqueous phenol electrolysis. J Electrochem Soc 140:903–911

    Article  Google Scholar 

  • Guan YQ, Chu QC, Fu L, Wu T, Ye JN (2006) Determination of phenolic antioxidants by micellar electrokinetic capillary chromatography with electrochemical detection. Food Chem 94:157–162

    Article  CAS  Google Scholar 

  • Guo L, Xie MY, Yan AP, Wan YQ, Wu YM (2006) Simultaneous determination of five synthetic antioxidants in edible vegetable oil by GC–MS. Anal Bioanal Chem 386:1881–1887

    Article  CAS  Google Scholar 

  • Issac S, Girish Kumar K (2009) Voltammetric determination of sulfamethoxazole at a multiwalled carbon nanotube modified glassy carbon sensor and its application studies. Drug Test Anal 1:350–354

    Article  CAS  Google Scholar 

  • Laviron E (1974) Surface linear potential sweep voltammetry equation of the peaks for a reversible reaction when interactions between the adsorbed molecules are taken into account. J Electroanal Chem 52:395–402

    Article  CAS  Google Scholar 

  • Litescu S, Radu GL, Diaconu M (2001) antioxidative power evaluation of some phenolic antioxidants—electroanalytical approach. Electroanalysis 13:804–806

    Article  Google Scholar 

  • Lonappan L, Girish Kumar K (2011) Carbon nanotube based sensor for voltammetric determination of pyridine-2-aldoxime methochloride. Sens Lett 9:541–545

    Article  CAS  Google Scholar 

  • Lonappan L, Issac S, Joseph R, Thomas D, Girish Kumar K (2011) Electrochemical studies of TAM using multiwalled carbon nanotube modified glassy carbon sensor. Micro Nano Lett 6:867–870

    Article  CAS  Google Scholar 

  • Luque M, Rios A, Valcarcel M (1999) A poly(vinyl choloride) graphite composite electrode for flow-injection amperometric determination of antioxidants. Anal Chim Acta 395:217–223

    Article  CAS  Google Scholar 

  • Mc Bridge HD, Evans DH (1973) Rapid voltammetric method for the estimation of tocopherols and antioxidants in oils and fats. Anal Chem 45:446–449

    Article  Google Scholar 

  • Medeiros RA, Rocha-Filho RC, Fatibello- Filho O (2010) Simultaneous voltammetric determination of phenolic antioxidants in food using a boron-doped diamond electrode. Food Chem 123:886–891

    Article  CAS  Google Scholar 

  • Michalkiewicz S, Mechanik M, Malyszko J (2004) Voltammetric study of some synthetic antioxidants on platinum microelectrodes in acetic acid medium. Electroanalysis 16:588–595

    Article  CAS  Google Scholar 

  • Ni Y, Wang L, Kokot S (2000) Voltammetric determination of butylated hydroxyanisole, butylated hydroxytoluene, propyl gallate and tert-butylhydroquinone by use of chemometric approaches. Anal Chim Acta 412:185–193

    Article  CAS  Google Scholar 

  • Perrin C, Meyer L (2002) Quantification of synthetic phenolic antioxidants in dry foods by reversed-phase HPLC with photodiode array detection. Food Chem 77:93–100

    Article  CAS  Google Scholar 

  • Randles JEB (1948) Cathode ray polarograph. Trans Faraday Soc 44:322–327

    Article  CAS  Google Scholar 

  • Riber J, Fuente C, Vazquez MD, Tascon ML, Batanero PS (2000) Electrochemical study of antioxidants at a polypyrrole electrode modified by a nickel phthalocyanine complex. Application to their HPLC separation and to their FIA system detections. Talanta 52:241–252

    Article  CAS  Google Scholar 

  • Richard Prabakar SJ, Sriman Narayanan S (2006) Surface modification of amine-functionalised graphite for preparation of cobalt hexacyanoferrate (CoHCF)-modified electrode: an amperometric sensor for determination of butylated hydroxyanisole (BHA). Anal Bioanal Chem 386:2107–2115

    Article  Google Scholar 

  • Rifkin SC, Evans DH (1976) Analytical evaluation of differential pulse voltammetry at stationary electrodes using computer-based instrumentation. Anal Chem 48:2174–2179

    Article  CAS  Google Scholar 

  • Ruiz MA, Garcia-Moreno E, Barbas C, Pingarron JM (1999) Determination of phenolic antioxidants by HPLC with amperometric detection at a nickel phthalocyanine polymer modified electrode. Electroanalysis 11:470–474

    Article  CAS  Google Scholar 

  • Saad B, Sing YY, Nawi MA, Hashim N, Ali ASM, Saleh MI (2007) Determination of synthetic phenolic antioxidants in food items using reversed-phase HPLC. Food Chem 105:389–394

    Article  CAS  Google Scholar 

  • Thomas D, Rajith L, Lonappan L, Issac S, Girish Kumar K (2012) Sensitive determination of nitrite in food samples. Food Anal Methods 5:752–758

    Article  Google Scholar 

  • Tsang SC, Chen YK, Harris PJE, Green MLH (1994) A simple chemical method of opening and filling carbon nanotubes. Nature 372:159–161

    Article  CAS  Google Scholar 

  • Vikraman AE, Rasheed Z, Rajith L, Lonappan LA, Girish Kumar K (2013) MWCNT-modified gold electrode sensor for the determination of propyl gallate in vegetable oils. Food Anal Methods 6:775–780

    Article  Google Scholar 

  • Wang J, Jiang M, Lu F (1998) Electrochemical quartz crystal microbalance investigation of surface fouling due to phenol oxidation. J Electroanal Chem 444:127–132

    Article  CAS  Google Scholar 

  • Williams GM (1993) Inhibition of chemical-induced experimental cancer of synthetic phenolic antioxidants. In: Williams GM, Sies H, Baker GT III, Erdmann JW Jr, Henry CJ (eds) Antioxidants: chemical, physiological, nutritional and toxicological aspects. Princeton Scientific Press, Princeton, pp 202–208

    Google Scholar 

  • Williams GM (1994) Interventive prophylaxis of liver cancer. Eur J Cancer Prev 3:89–99

    Article  CAS  Google Scholar 

  • Xiu LQ, Chao J, Yan-Yan S (2009) Analysis of synthetic antioxidants and preservatives in edible vegetable oil by HPLC/TOF-MS. Food Chem 113:692–700

    Article  Google Scholar 

  • Yanez-Sedeno P, Pingarron JM, DÌez LMP (1991) Determination of tert-butylhydroxyanisole and tert-butylhydroxytoluene by flow injection with amperometric detection. Anal Chim Acta 252:153–159

    Article  CAS  Google Scholar 

  • Yi H, Wu K, Hu S, Cui D (2001) Talanta 55:1205

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors are grateful to the University Grants Commission (UGC), Council of Scientific and Industrial Research (CSIR), and Defence Research and Development Organisation (DRDO), India, for financial assistance.

Compliance with Ethics Requirements

Krishnapillai Girish Kumar has received research grants from the Defence Research and Development Organisation (DRDO), India.

Conflict of Interest

Zafna Rasheed declares that she has no conflict of interest. Anuja Elevathoor Vikraman declares that she has no conflict of interest. Divya Thomas declares that she has no conflict of interest. Jesny Siri Jagan declares that she has no conflict of interest. This article does not contain any studies with human or animal subjects.

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Authors and Affiliations

  1. Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, 682 022, India

    Zafna Rasheed, Anuja Elevathoor Vikraman, Divya Thomas, Jesny Siri Jagan & Krishnapillai Girish Kumar

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  1. Zafna Rasheed
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  2. Anuja Elevathoor Vikraman
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  3. Divya Thomas
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  4. Jesny Siri Jagan
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  5. Krishnapillai Girish Kumar
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Correspondence to Krishnapillai Girish Kumar.

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Rasheed, Z., Vikraman, A.E., Thomas, D. et al. Carbon-Nanotube-Based Sensor for the Determination of Butylated Hydroxyanisole in Food Samples. Food Anal. Methods 8, 213–221 (2015). https://doi.org/10.1007/s12161-014-9894-7

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  • DOI: https://doi.org/10.1007/s12161-014-9894-7

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