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Ultrasensitive Detection of Enrofloxacin in Chicken Muscles by Surface-Enhanced Raman Spectroscopy Using Amino-Modified Glycidyl Methacrylate-Ethylene Dimethacrylate (GMA-EDMA) Powdered Porous Material

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Abstract

Illegally use of enrofloxacin in chicken has raised serious concerns due to its negative effects on public health. In this study, surface-enhanced Raman spectroscopy (SERS) using amino-modified glycidyl methacrylate-ethylene dimethacrylate (GMA-EDMA) powdered porous material was developed and validated to detect enrofloxacin in chicken muscles. By this method, enrofloxacin in chicken muscles was successfully detected at a concentration of 0.01 mg kg−1, which was lower than the legal maximum residue limit. And the unique “fingerprint-like” spectral patterns of enrofloxacin obtained from SERS spectra could be used for identification and characterization. Compared with high-performance liquid chromatography, the assay of six samples with SERS was rapid in less than 40 min, and the detection was highly sensitive. The results demonstrate that SERS using GMA-EDMA powdered porous material can be potentially employed as a screening tool for rapid detection of residual drugs in a large amount of food samples.

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Acknowledgments

The authors gratefully acknowledge the financial support for this project from National Science Foundation of China (grant no: 21205041).

Conflict of interest

Ying Xu declares that she has no conflict of interest. Yiping Du declares that he has no conflict of interest. Qingqing Li declares that she has no conflict of interest. Xuan Wang declares that he has no conflict of interest. Yingcheng Pan declares that he has no conflict of interest. Han Zhang declares that he has no conflict of interest. Ting Wu declares that she has no conflict of interest. Huilian Hu declares that she has no conflict of interest. In this article, all institutional and national guidelines for the care and use of laboratory animals were followed.

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Authors and Affiliations

  1. Shanghai Key Laboratory of Functional Materials Chemistry, and Research Centre of Analysis and Test, East China University of Science and Technology, Shanghai, 200237, China

    Ying Xu, Yiping Du, Qingqing Li, Xuan Wang, Yingcheng Pan, Han Zhang, Ting Wu & Huilian Hu

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  1. Ying Xu
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  2. Yiping Du
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  3. Qingqing Li
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  4. Xuan Wang
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  5. Yingcheng Pan
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  6. Han Zhang
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  7. Ting Wu
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  8. Huilian Hu
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Correspondence to Yiping Du.

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Xu, Y., Du, Y., Li, Q. et al. Ultrasensitive Detection of Enrofloxacin in Chicken Muscles by Surface-Enhanced Raman Spectroscopy Using Amino-Modified Glycidyl Methacrylate-Ethylene Dimethacrylate (GMA-EDMA) Powdered Porous Material. Food Anal. Methods 7, 1219–1228 (2014). https://doi.org/10.1007/s12161-013-9736-z

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