Skip to main content
Log in

Prevention of Stress-Provoked Endothelial Injury by Values Affirmation: a Proof of Principle Study

  • Brief Report
  • Published:
Annals of Behavioral Medicine

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

References

  1. Selye H. The Stress of Life. New York: McGraw-Hill; 1956.

    Google Scholar 

  2. MacLean PD. Psychosomatic disease and the visceral brain; recent developments bearing on the Papez theory of emotion. Psychosom Med. 1949; 11(6): 338-353.

    Article  CAS  PubMed  Google Scholar 

  3. Dimsdale JE. Psychological stress and cardiovascular disease. J Am Coll Cardiol. 2008; 51(13): 1237-1246.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Wilbert-Lampen U, Leistner D, Greven S, et al. Cardiovascular events during World Cup soccer. N Engl J Med. 2008; 358(5): 475-483.

    Article  CAS  PubMed  Google Scholar 

  5. Rozanski A, Bairey CN, Krantz DS, et al. Mental stress and the induction of silent myocardial ischemia in patients with coronary artery disease. N Engl J Med. 1988; 318(16): 1005-1012.

    Article  CAS  PubMed  Google Scholar 

  6. Haynes SG, Feinleib M, Kannel WB. The relationship of psychosocial factors to coronary heart disease in the Framingham Study. III. Eight-year incidence of coronary heart disease. Am J Epidemiol. 1980; 111(1): 37-58.

    CAS  PubMed  Google Scholar 

  7. Rosengren A, Hawken S, Ounpuu S, et al. Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): Case–control study. Lancet. 2004; 364(9438): 953-962.

    Article  PubMed  Google Scholar 

  8. Boulanger CM, Amabile N, Tedgui A. Circulating microparticles: A potential prognostic marker for atherosclerotic vascular disease. Hypertension. 2006; 48(2): 180-186.

    Article  CAS  PubMed  Google Scholar 

  9. Deanfield JE, Halcox JP, Rabelink TJ. Endothelial function and dysfunction: Testing and clinical relevance. Circulation. 2007; 115(10): 1285-1295.

    PubMed  Google Scholar 

  10. VanWijk MJ, VanBavel E, Sturk A, Nieuwland R. Microparticles in cardiovascular diseases. Cardiovasc Res. 2003; 59(2): 277-287.

    Article  CAS  PubMed  Google Scholar 

  11. Lynch SF, Ludlam CA. Plasma microparticles and vascular disorders. Br J Haematol. 2007; 137(1): 36-48.

    CAS  PubMed  Google Scholar 

  12. Simak J, Gelderman MP, Yu H, Wright V, Baird AE. Circulating endothelial microparticles in acute ischemic stroke: A link to severity, lesion volume and outcome. J Thromb Haemost. 2006; 4(6): 1296-1302.

    Article  CAS  PubMed  Google Scholar 

  13. Vanwijk MJ, Svedas E, Boer K, Nieuwland R, Vanbavel E, Kublickiene KR. Isolated microparticles, but not whole plasma, from women with preeclampsia impair endothelium-dependent relaxation in isolated myometrial arteries from healthy pregnant women. Am J Obstet Gynecol. 2002; 187(6): 1686-1693.

    Article  PubMed  Google Scholar 

  14. Dickerson SS, Kemeny ME. Acute stressors and cortisol responses: A theoretical integration and synthesis of laboratory research. Psychol Bull. 2004; 130(3): 355-391.

    Article  PubMed  Google Scholar 

  15. Kemeny ME, Schedlowski M. Understanding the interaction between psychosocial stress and immune-related diseases: A stepwise progression. Brain Behav Immun. 2007; 21(8): 1009-1018.

    Article  CAS  PubMed  Google Scholar 

  16. Berntson GG, Cacioppo JT, Binkley PF, Uchino BN, Quigley KS, Fieldstone A. Autonomic cardiac control. III. Psychological stress and cardiac response in autonomic space as revealed by pharmacological blockades. Psychophysiology. 1994; 31(6): 599-608.

    Article  CAS  PubMed  Google Scholar 

  17. Shimbo D, Rosenberg LB, Chaplin W, et al. Endothelial cell activation, reduced endothelial cell reparative capacity, and impaired endothelial-dependent vasodilation after anger provocation. Int J Cardiol. 2013; 167(3): 1064-1065.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Creswell JD, Welch WT, Taylor SE, Sherman DK, Gruenewald TL, Mann T. Affirmation of personal values buffers neuroendocrine and psychological stress responses. Psychol Sci. 2005; 16(11): 846-851.

    Article  PubMed  Google Scholar 

  19. Sherman DK, Bunyan DP, Creswell JD, Jaremka LM. Psychological vulnerability and stress: The effects of self-affirmation on sympathetic nervous system responses to naturalistic stressors. Health Psychol. 2009; 28(5): 554-562.

    Article  PubMed  Google Scholar 

  20. Cohen GL, Garcia J, Apfel N, Master A. Reducing the racial achievement gap: A social-psychological intervention. Science. 2006; 313(5791): 1307-1310.

    Article  CAS  PubMed  Google Scholar 

  21. Cohen GL, Garcia J, Purdie-Vaughns V, Apfel N, Brzustoski P. Recursive processes in self-affirmation: Intervening to close the minority achievement gap. Science. 2009; 324(5925): 400-403.

    Article  CAS  PubMed  Google Scholar 

  22. Creswell JD, Dutcher JM, Klein WM, Harris PR, Levine JM. Self-affirmation improves problem-solving under stress. PLoS One. 2013; 8(5), e62593.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Miyake A, Kost-Smith LE, Finkelstein ND, Pollock SJ, Cohen GL, Ito TA. Reducing the gender achievement gap in college science: A classroom study of values affirmation. Science. 2010; 330(6008): 1234-1237.

    Article  CAS  PubMed  Google Scholar 

  24. Bernal-Mizrachi L, Jy W, Jimenez JJ, et al. High levels of circulating endothelial microparticles in patients with acute coronary syndromes. Am Heart J. 2003; 145(6): 962-970.

    Article  PubMed  Google Scholar 

  25. Jy W, Horstman LL, Jimenez JJ, et al. Measuring circulating cell-derived microparticles. J Thromb Haemost. 2004; 2(10): 1842-1851.

    Article  CAS  PubMed  Google Scholar 

  26. Cohen GL, Sherman DK. The psychology of change: Self-affirmation and social psychological intervention. Annu Rev Psychol. 2014; 65: 333-371.

    Article  PubMed  Google Scholar 

  27. Steele CM. The psychology of self-affirmation: Sustaining the integrity of the self. Adv Exp Soc Psychol. 1988; 21: 261-302.

    Article  Google Scholar 

  28. Sherman DK, Hartson KA. Reconciling self-protection with self-improvement. In: Alicke MD, Sedikides C, eds. Handbook of self-enhancement and self-protection. New York: Guildford Press; 2011: 128-151.

    Google Scholar 

  29. Kirschbaum C, Pirke KM, Hellhammer DH. The ‘Trier Social Stress Test’—A tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology. 1993; 28(1–2): 76-81.

    Article  CAS  PubMed  Google Scholar 

  30. Cacioppo JT, Berntson GG, Binkley PF, Quigley KS, Uchino BN, Fieldstone A. Autonomic cardiac control. II. Noninvasive indices and basal response as revealed by autonomic blockades. Psychophysiology. 1994; 31(6): 586-598.

    Article  CAS  PubMed  Google Scholar 

  31. Wager TD, van Ast VA, Hughes BL, Davidson ML, Lindquist MA, Ochsner KN. Brain mediators of cardiovascular responses to social threat, part II: Prefrontal-subcortical pathways and relationship with anxiety. Neuroimage. 2009; 47(3): 836-851.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Ghiadoni L, Donald AE, Cropley M, et al. Mental stress induces transient endothelial dysfunction in humans. Circulation. 2000; 102(20): 2473-2478.

    Article  CAS  PubMed  Google Scholar 

  33. Gottdiener JS, Kop WJ, Hausner E, McCeney MK, Herrington D, Krantz DS. Effects of mental stress on flow-mediated brachial arterial dilation and influence of behavioral factors and hypercholesterolemia in subjects without cardiovascular disease. Am J Cardiol. 2003; 92(6): 687-691.

    Article  PubMed  Google Scholar 

  34. Jimenez JJ, Jy W, Mauro LM, Horstman LL, Soderland C, Ahn YS. Endothelial microparticles released in thrombotic thrombocytopenic purpura express von Willebrand factor and markers of endothelial activation. Br J Haematol. 2003; 123(5): 896-902.

    Article  PubMed  Google Scholar 

  35. Roy M, Shohamy D, Wager TD. Ventromedial prefrontal-subcortical systems and the generation of affective meaning. Trends Cogn Sci. 2012; 16(3): 147-156.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Gianaros PJ, Horenstein JA, Cohen S, et al. Perigenual anterior cingulate morphology covaries with perceived social standing. Soc Cogn Affect Neurosci. 2007; 2(3): 161-173.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Schmader T, Johns M, Forbes C. An integrated process model of stereotype threat effects on performance. Psychol Rev. 2008; 115(2): 336-356.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Dedovic K, Renwick R, Mahani NK, Engert V, Lupien SJ, Pruessner JC. The Montreal Imaging Stress Task: Using functional imaging to investigate the effects of perceiving and processing psychosocial stress in the human brain. J Psychiatry Neurosci. 2005; 30(5): 319-325.

    PubMed  PubMed Central  Google Scholar 

  39. van Ast VA, Spicer J, Smith EE, et al. Brain mechanisms of social threat effects on working memory. Cereb Cortex. 2014. http://doi.org/10.1093/cercor/bhu206.

  40. Denny BT, Kober H, Wager TD, Ochsner KN. A meta-analysis of functional neuroimaging studies of self- and other judgments reveals a spatial gradient for mentalizing in medial prefrontal cortex. J Cogn Neurosci. 2012; 24(8): 1742-1752.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Northoff G, Heinzel A, de Greck M, Bermpohl F, Dobrowolny H, Panksepp J. Self-referential processing in our brain—A meta-analysis of imaging studies on the self. Neuroimage. 2006; 31(1): 440-457.

    Article  PubMed  Google Scholar 

  42. Walton GM, Cohen GL. A brief social-belonging intervention improves academic and health outcomes of minority students. Science. 2011; 331(6023): 1447-1451.

    Article  CAS  PubMed  Google Scholar 

  43. Button KS, Ioannidis JP, Mokrysz C, et al. Power failure: Why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci. 2013; 14(5): 365-376.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tor D. Wager Ph.D..

Ethics declarations

Funding

This work was supported by the National Institutes of Health (NIH R21 MH082308 to T.D.W and NIH R01 HL116470 to D.S.).

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Conflict of Interest

Authors’ Statement of Conflict of Interest and Adherence to Ethical Standards Authors Spicer, Shimbo, Johnston, Harlapur, Purdie-Vaughns, Cook, Fu, Burg, and Wager declare that they have no conflict of interest. All procedures, including the informed consent process, were conducted in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000

Additional information

Julie Spicer Ph.D. and Daichi Shimbo M.D. contributed equally to this work.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Spicer, J., Shimbo, D., Johnston, N. et al. Prevention of Stress-Provoked Endothelial Injury by Values Affirmation: a Proof of Principle Study. ann. behav. med. 50, 471–479 (2016). https://doi.org/10.1007/s12160-015-9756-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12160-015-9756-6

Keywords

Navigation