Abstract
Background
Type 2 diabetes is associated with low-grade systemic inflammation, increasing the risk for various adverse health outcomes.
Purpose
Our objective was to investigate the association between C-reactive protein (CRP), a marker for systemic inflammation, and lifestyle factors in a national sample of people with type 2 diabetes.
Methods
This study analyzed data from 1,086 men and women with diabetes, who completed the 1999–2004 NHANES. Lifestyle factors included diet quality, body mass index (BMI), smoking, and physical activity.
Results
Stratified logistic regression showed that for both men and women, BMI was a strong predictor of elevated CRP after adjusting for age, energy intake, race/ethnicity, medications, diabetes duration, and glycosylated hemoglobin. However, among men, but not among women, the likelihood of elevated CRP increased with lower diet quality and physical inactivity.
Conclusions
Among people with type 2 diabetes, higher levels of CRP were associated with lower diet quality and physical inactivity among men, and with obesity among both men and women.
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Acknowledgments
SJ was supported by the Washington University School of Medicine. DBJ was supported by the Health Behavior, Communication, and Outreach Core of the Siteman Cancer Center, which is supported in part by the National Cancer Institute Cancer Center Support Grant (P30 CA91842) to the Siteman Cancer Center and the Clinical and Translational Sciences Award (UL1 RR024992) to Washington University School of Medicine. NOD was supported in part by grants from NIH (DK 56260, DK 52574, HL 38180).
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The authors have no conflict of interest to disclose.
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Jarvandi, S., Davidson, N.O., Jeffe, D.B. et al. Influence of Lifestyle Factors on Inflammation in Men and Women with Type 2 Diabetes: Results from the National Health and Nutrition Examination Survey, 1999–2004. ann. behav. med. 44, 399–407 (2012). https://doi.org/10.1007/s12160-012-9397-y
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DOI: https://doi.org/10.1007/s12160-012-9397-y