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Clinical and pathological implications of GSTM1 and GSTT1 gene deletions in sporadic breast cancer

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Oncology Reviews

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Abstract

There is a lack of consensus about the influence of GST M1/T1 gene deletions (DEL) on sporadic breast cancer (SBC). To evaluate the occurrence of DEL in 177 SBC cases and in 169 controls, and compare clinical and biological characteristics. A lower frequency of GSTM1 DEL was observed in mulatto women, OR=0.48 (0.24–0.98). The risk of nuclear grade 3 tumors (GN3) was lower in patients with GSTT1 DEL, OR=0.37 (0.15–0.90). DEL of at least one gene (ALOG) was associated with women who had not breastfed, OR=0.41 (0.19–0.88), and with negative hormone receptor, HR−, ORadj=2.25 (1.03–4.90). Both genes deleted (BGD) was associated with non-classic invasive ductal carcinoma (NCDC), ORadj=12.09 (1.03–142.03). Mulatto women with SBC had a lower frequency of GSTM1 DEL, while tumors differentiated were related to GSTT1 DEL. HR-tumors were related with DEL ALOG, and the BGD was associated with a greater risk of NCDC.

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Authors and Affiliations

  1. Caixa Postal 6081 - CEP - 13083-970, Cidade Universitária Zeferino Vaz, Barão Geraldo, Campinas, SP, Brazil

    Maria Salete Costa Gurgel

  2. Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas UNICAMP, Campinas, Brazil

    Cassio Cardoso Filho, Julia Yoriko Shinzato, Luiz Carlos Zeferino & Maria Salete Costa Gurgel

  3. Laboratory of Conventional and Molecular Cytogenetics, Blood Center/UNICAMP, Campinas, Brazil

    Gustavo Lourenço

  4. Department of Clinical Medicine, FCM/UNICAMP, Campinas, Brazil

    Fernando Ferreira Costa & Carmen Silvia Passos Lima

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  1. Cassio Cardoso Filho
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Correspondence to Maria Salete Costa Gurgel.

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Cardoso Filho, C., Lourenço, G., Shinzato, J.Y. et al. Clinical and pathological implications of GSTM1 and GSTT1 gene deletions in sporadic breast cancer. Oncol Rev 2, 36–43 (2008). https://doi.org/10.1007/s12156-008-0054-4

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  • DOI: https://doi.org/10.1007/s12156-008-0054-4

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