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Influence of acquisition orbit on phase analysis of gated single photon emission computed tomography myocardial perfusion imaging for assessment of left ventricular mechanical dyssynchrony

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Abstract

Objective

The association between left ventricular (LV) dyssynchrony parameters, given by phase analysis of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), and acquisition orbits is unclear. The aim of this study was to assess the dependence of LV dyssynchrony parameters on acquisition orbits.

Methods

Ninety-nine patients who underwent 201Tl-gated SPECT MPI were categorized into minor hypoperfusion or major hypoperfusion groups. Forty-four patients who underwent 99mTc-tetrofosmin-gated SPECT MPI were categorized into minor hypoperfusion or major hypoperfusion groups. The major hypoperfusion group with 201Tl was divided into inferior or non-inferior wall hypoperfusion subgroups, and anteroseptal or non-anteroseptal wall hypoperfusion subgroups. Gated SPECT MPI data over a 360° acquisition orbit (360° images) and a 180° acquisition orbit (180° images) were reconstructed, and histogram bandwidth (HBW) and phase standard deviation (PSD) were compared.

Results

Between 360° and 180° images with 201Tl, there were significant differences in HBW and PSD both globally (HBW 34.8 ± 16.6 vs. 29.1 ± 10.2; PSD 8.8 ± 4.9 vs. 7.0 ± 2.3, p < 0.05 for both) and in the inferior wall (HBW 29.5 ± 15.5 vs. 23.3 ± 9.0; PSD 7.6 ± 4.6 vs. 5.6 ± 2.4, p < 0.001 for both) in the major hypoperfusion group, and also in the inferior wall in all subgroups of the major hypoperfusion group. In contrast, no segment had any significant differences in HBW or PSD between 360° and 180° images with 99mTc.

Conclusion

Differences in acquisition orbit had a significant influence on HBW and PSD with 201Tl-gated SPECT MPI in the inferior wall in patients with major hypoperfusion myocardium.

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References

  1. Westenberg JJM, Lamb HJ, van der Geest RJ, Bleeker GB, Holman ER, Schalij MJ, et al. Assessment of left ventricular dyssynchrony in patients with conduction delay and idiopathic dilated cardiomyopathy: head-to-head comparison between tissue doppler imaging and velocity-encoded magnetic resonance imaging. J Am Coll Cardiol. 2006;47:2042–8.

    Article  PubMed  Google Scholar 

  2. Vilain D, Daou D, Casset-Senon D, Faraggi M, Le Guludec D. Optimal 3-dimensional method for right and left ventricular fourier phase analysis in electrocardiography-gated blood-pool SPECT. J Nucl Cardiol. 2001;8:371–8.

    Article  CAS  PubMed  Google Scholar 

  3. Germano G, Erel J, Lewin H, Kavanagh PB, Berman DS. Automatic quantitation of regional myocardial wall motion and thickening from gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol. 1997;30:1360–7.

    Article  CAS  PubMed  Google Scholar 

  4. Chen J, Garcia EV, Folks RD, Cooke CD, Faber TL, Tauxe EL, et al. Onset of left ventricular mechanical contraction as determined by phase analysis of ECG-gated myocardial perfusion SPECT imaging: development of a diagnostic tool for assessment of cardiac mechanical dyssynchrony. J Nucl Cardiol. 2005;12:687–95.

    Article  PubMed  Google Scholar 

  5. Garcia EV, Faber TL, Cooke CD, Folks RD, Chen J, Santana C. The increasing role of quantification in clinical nuclear cardiology: the Emory approach. J Nucl Cardiol. 2007;14:420–32.

    Article  PubMed  Google Scholar 

  6. Germano G, Kavanagh PB, Slomka PJ, Van Kriekinge SD, Pollard G, Berman DS. Quantitation in gated perfusion SPECT imaging: the Cedars-Sinai approach. J Nucl Cardiol. 2007;14:433–54.

    Article  PubMed  Google Scholar 

  7. Van Kriekinge SD, Nishina H, Ohba M, Berman DS, Germano G. Automatic global and regional phase analysis from gated myocardial perfusion SPECT imaging: application to the characterization of ventricular contraction in patients with left bundle branch block. J Nucl Med. 2008;49:1790–7.

    Article  PubMed  Google Scholar 

  8. Ypenburg C, Schalij MJ, Bleeker GB, Steendijk P, Boersma E, Dibbets-Schneider P, et al. Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients. Eur Heart J. 2007;28:33–41.

    Article  PubMed  Google Scholar 

  9. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, et al. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346:1845–53.

    Article  PubMed  Google Scholar 

  10. Leclercq C, Kass DA. Retiming the failing heart: principles and current clinical status of cardiac resynchronization. J Am Coll Cardiol. 2002;39:194–201.

    Article  PubMed  Google Scholar 

  11. Henneman MM, Chen J, Ypenburg C, Dibbets P, Bleeker GB, Boersma E, et al. Phase analysis of gated myocardial perfusion single-photon emission computed tomography compared with tissue Doppler imaging for the assessment of left ventricular dyssynchrony. J Am Coll Cardiol. 2007;49:1708–14.

    Article  PubMed  Google Scholar 

  12. Boogers MM, Van Kriekinge SD, Henneman MM, Ypenburg C, Van Bommel RJ, Boersma E, et al. Quantitative gated SPECT-derived phase analysis on gated myocardial perfusion SPECT detects left ventricular dyssynchrony and predicts response to cardiac resynchronization therapy. J Nucl Med. 2009;50:718–25.

    Article  PubMed  Google Scholar 

  13. Henneman MM, Chen J, Dibbets-Schneider P, Stokkel MP, Bleeker BG, Ypenburg C, et al. Can LV dyssynchrony as assessed with phase analysis on gated myocardial perfusion SPECT predict response to CRT? J Nucl Med. 2007;48:1104–11.

    Article  PubMed  Google Scholar 

  14. Chen C-C, Shen T-Y, Chang M-C, Hung G-U, Chen W-C, Kao C-H, et al. Stress-induced myocardial ischemia is associated with early post-stress left ventricular mechanical dyssynchrony as assessed by phase analysis of 201Tl gated SPECT myocardial perfusion imaging. Eur J Nucl Med Mol Imaging. 2012;39:1904–9.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Huang W-S, Huang C-H, Lee C-L, Chen C-P, Hung G-U, Chen J. Relation of early post-stress left ventricular dyssynchrony and the extent of angiographic coronary artery disease. J Nucl Cardiol. 2014;21:1048–56.

    Article  PubMed  Google Scholar 

  16. Liu Y-H, Lam PT, Sinusas AJ, Wackers FJT. Differential effect of 180 degrees and 360 degrees acquisition orbits on the accuracy of SPECT imaging: quantitative evaluation in phantoms. J Nucl Med. 2002;43:1115–24.

    PubMed  Google Scholar 

  17. Nakajima K, Taki J, Yamamoto W, Michigishi T, Tonami N. Effect of 360 degrees and 180 degrees rotation SPET acquisitions on myocardial polar map: comparison of 201Tl-, 99Tcm- and 123I-labelled radiopharmaceuticals. Nucl Med Commun. 1998;19:315–25.

    Article  CAS  PubMed  Google Scholar 

  18. Nakata T, Hashimoto A, Matsuki T, Yoshinaga K, Tsukamoto K, Tamaki N. Prognostic value of automated SPECT scoring system for coronary artery disease in stress myocardial perfusion and fatty acid metabolism imaging. Int J Cardiovasc Imaging. 2013;29:253–62.

    Article  PubMed  Google Scholar 

  19. Kusuoka H, Nishimura S, Yamashina A, Nakajima K, Nishimura T. Surveillance study for creating the national clinical database related to ECG-gated myocardial perfusion SPECT of ischemic heart disease: J-ACCESS study design. Ann Nucl Med. 2006;20:195–202.

    Article  PubMed  Google Scholar 

  20. Nishimura T, Nakajima K, Kusuoka H, Yamashina A, Nishimura S. Prognostic study of risk stratification among Japanese patients with ischemic heart disease using gated myocardial perfusion SPECT: J-ACCESS study. Eur J Nucl Med Mol Imaging. 2008;35:319–28.

    Article  PubMed  Google Scholar 

  21. Matsuo S, Nakajima K, Horie M, Nakae I, Nishimura T. Prognostic value of normal stress myocardial perfusion imaging in Japanese population. Circ J. 2007;72:611–7.

    Article  Google Scholar 

  22. Matsuo S, Nakajima K, Yamasaki Y, Kashiwagi A, Nishimura T. Prognostic value of normal stress myocardial perfusion imaging and ventricular function in Japanese asymptomatic patients with type 2 diabetes. Circ J. 2010;74:1916–21.

    Article  CAS  PubMed  Google Scholar 

  23. Chen J, Garcia EV, Bax JJ, Iskandrian AE, Borges-Neto S, et al. SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony. J Nucl Cardiol. 2011;18:685–94.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Galt JR, Garcia EV, Robbins WL. Effects of myocardial wall thickness on SPECT quantification. IEEE Trans Med Imaging. 1990;9:144–50.

    Article  CAS  PubMed  Google Scholar 

  25. He ZX, Cwajg E, Preslar JS, Mahmarian JJ, Verani MS. Accuracy of left ventricular ejection fraction determined by gated myocardial perfusion SPECT with Tl-201 and Tc-99m sestamibi: comparison with first-pass radionuclide angiography. J Nucl Cardiol. 1999;6:412–7.

    Article  CAS  PubMed  Google Scholar 

  26. Germano G, Erel J, Kiat H, Kavanagh PB, Berman DS. Quantitative LVEF and qualitative regional function from gated thallium-201 perfusion SPECT. J Nucl Med. 1997;38:749–54.

    CAS  PubMed  Google Scholar 

  27. Kortelainen MJ, Koivumäki TM, Vauhkonen MJ, Hakulinen MA. Dependence of left ventricular functional parameters on image acquisition time in cardiac-gated myocardial perfusion SPECT. J Nucl Cardiol. 2015;22:643–51.

    Article  PubMed  Google Scholar 

  28. Beller GA. Diagnostic accuracy of thallium-201 myocardial perfusion imaging. Circulation. 1991;84:I1–I6.

    Article  CAS  PubMed  Google Scholar 

  29. Wang SJ, Chen YT, Hwang CL, Lin MS, Kao CH, Yeh SH. 99mTc-sestamibi can improve the inferior attenuation of TL-201 myocardial spect imaging. Int J Card Imaging. 1993;9:87–92.

    Article  CAS  PubMed  Google Scholar 

  30. Harel F, Génin R, Daou D, Lebtahi R, Delahaye N, Helal BO, et al. Clinical impact of combination of scatter, attenuation correction, and depth-dependent resolution recovery for 201Tl studies. J Nucl Med. 2001;42:1451–6.

    Google Scholar 

  31. Li D, Zhou Y, Feng J, Yuan D, Cao K, Garcia EV, et al. Impact of image reconstruction on phase analysis of ECG-gated myocardial perfusion SPECT studies. Nucl Med Commun. 2009;30:700–5.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Dorbala S, Di Carli MF, Delbeke D, Abbara S, DePuey EG, Dilsizian V, et al. SNMMI/ASNC/SCCT guideline for cardiac SPECT/CT and PET/CT 1.0. J Nucl Med. 2013;54:1485–507.

    Article  PubMed  Google Scholar 

  33. Nakajima K, Okuda K, Kawano M, Matsuo S, Slomka P, Germano G, et al. The importance of population-specific normal database for quantification of myocardial ischemia: comparison between Japanese 360 and 180-degree databases and a US database. J Nucl Cardiol. 2009;16:422–30.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Kindai University Nara Hospital, 1248-1, Otoda-cho, Ikoma, Nara, Japan

    Tomofumi Misaka, Takamichi Ito, Tsutomu Syomura, Masanobu Uemura & Kaoru Okajima

  2. Faculty of Medicine, Institute of Advanced Clinical Medicine, Kindai University, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan

    Makoto Hosono

  3. Department of Radioisotope Medicine, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4, Sakamoto, Nagasaki, Nagasaki, Japan

    Takashi Kudo

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  1. Tomofumi Misaka
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Correspondence to Makoto Hosono.

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Misaka, T., Hosono, M., Kudo, T. et al. Influence of acquisition orbit on phase analysis of gated single photon emission computed tomography myocardial perfusion imaging for assessment of left ventricular mechanical dyssynchrony. Ann Nucl Med 31, 235–244 (2017). https://doi.org/10.1007/s12149-017-1151-x

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  • DOI: https://doi.org/10.1007/s12149-017-1151-x

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