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Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

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Abstract

Introduction

The impact of age is crucial and must be taken into account when applying a voxel-based quantitative analysis on brain images from [18F]-fluorodeoxyglucose Positron Emission Tomography (FDG-PET). This study aimed to determine whether age-related changes in brain FDG-PET images are more accurately assessed when the conventional statistical parametric mapping (SPM) normalization method is used with an adaptive template, obtained from analysed PET images using a Block-Matching (BM) algorithm to fit with the characteristics of these images.

Methods

Age-related changes in FDG-PET images were computed with linear models in 84 neurologically healthy subjects (35 women, 19 to 82-year-old), and compared between results provided by the SPM normalization algorithm applied on its dedicated conventional template or on the adaptive BM template. A threshold P value of 0.05 was used together with a family-wise error correction.

Results

The age-related changes in FDG-PET images were much more apparent when computed with the adaptive template than with the conventional template as evidenced by: (1) stronger correlation coefficients with age for the overall frontal and temporal uptake values (respective R 2 values of 0.20 and 0.07) and (2) larger extents of involved areas (13 and 5 % of whole brain template volume, respectively), leading to reveal several age-dependent areas (especially in dorsolateral prefrontal, inferior temporal/fusiform and primary somatosensory cortices).

Conclusion

Age-related changes in brain FDG uptake may be more accurately determined when applying the SPM method of voxel-based quantitative analysis on a template that best fits the characteristics of the analysed TEP images.

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Acknowledgments

The authors thank Pierre Pothier, for critical review of the manuscript, and the Nancyclotep experimental imaging platform, for organizational support.

Author information

Author notes

    Authors and Affiliations

    1. Department of Nuclear Medicine and Nancyclotep Experimental Imaging Platform, CHU Nancy, Allée du Morvan, Vandœuvre, 54000, Nancy, France

      Axel Van Der Gucht, Antoine Verger, Yalcin Yagdigul, Véronique Roch, Sylvain Poussier, Gilles Karcher & Pierre-Yves Marie

    2. INSERM, UMR 947, 54000, Nancy, France

      Antoine Verger, Véronique Roch & Sylvain Poussier

    3. Faculty of Medicine, University of Lorraine, 54000, Nancy, France

      Antoine Verger, Véronique Roch, Sylvain Poussier, Louis Maillard, Gilles Karcher & Pierre-Yves Marie

    4. Department of Nuclear Medicine, AP-HM, Hospital “La Timone”, 13000, Marseille, France

      Eric Guedj

    5. CNRS UMR 7289, Institut de Neurosciences de la Timone, INT, 13000, Marseille, France

      Eric Guedj

    6. INRIA Sophia Antipolis-Méditerranée, 06902, Sophia Antipolis, France

      Grégoire Malandain

    7. CIC-IT, CHU Nancy, 5400, Nancy, France

      Gabriela Hossu

    8. INSERM, CIC-IT 1433, 5400, Nancy, France

      Gabriela Hossu

    9. Department of Neurology, CHU-Nancy, 54000, Nancy, France

      Louis Maillard

    10. CRAN, UMR 7039, Université de Lorraine-CNRS, 54500, Vandoeuvre, France

      Gilles Karcher

    11. INSERM, U1116, 54000, Nancy, France

      Pierre-Yves Marie

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    1. Axel Van Der Gucht
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    Correspondence to Axel Van Der Gucht.

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    Ethical standards

    The procedure followed was in accordance with the ethical standards and guidelines of the responsible committee on human experimentation.

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    A. Van Der Gucht and A. Verger contributed equally to this work.

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    Van Der Gucht, A., Verger, A., Guedj, E. et al. Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis. Ann Nucl Med 29, 921–928 (2015). https://doi.org/10.1007/s12149-015-1022-2

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    • DOI: https://doi.org/10.1007/s12149-015-1022-2

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