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Performance measurement of PSF modeling reconstruction (True X) on Siemens Biograph TruePoint TrueV PET/CT

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Abstract

Objective

The Siemens Biograph TruePoint TrueV (B-TPTV) positron emission tomography (PET) scanner performs 3D PET reconstruction using a system matrix with point spread function (PSF) modeling (called the True X reconstruction). PET resolution was dramatically improved with the True X method. In this study, we assessed the spatial resolution and image quality on a B-TPTV PET scanner. In addition, we assessed the feasibility of animal imaging with a B-TPTV PET and compared it with a microPET R4 scanner.

Methods

Spatial resolution was measured at center and at 8 cm offset from the center in transverse plane with warm background activity. True X, ordered subset expectation maximization (OSEM) without PSF modeling, and filtered back-projection (FBP) reconstruction methods were used. Percent contrast (% contrast) and percent background variability (% BV) were assessed according to NEMA NU2-2007. The recovery coefficient (RC), non-uniformity, spill-over ratio (SOR), and PET imaging of the Micro Deluxe Phantom were assessed to compare image quality of B-TPTV PET with that of the microPET R4.

Results

When True X reconstruction was used, spatial resolution was <3.65 mm with warm background activity. % contrast and % BV with True X reconstruction were higher than those with the OSEM reconstruction algorithm without PSF modeling. In addition, the RC with True X reconstruction was higher than that with the FBP method and the OSEM without PSF modeling method on the microPET R4. The non-uniformity with True X reconstruction was higher than that with FBP and OSEM without PSF modeling on microPET R4. SOR with True X reconstruction was better than that with FBP or OSEM without PSF modeling on the microPET R4.

Conclusions

This study assessed the performance of the True X reconstruction. Spatial resolution with True X reconstruction was improved by 45 % and its % contrast was significantly improved compared to those with the conventional OSEM without PSF modeling reconstruction algorithm. The noise level was higher than that with the other reconstruction algorithm. Therefore, True X reconstruction should be used with caution when quantifying PET data.

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References

  1. Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N. Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging. Eur J Nucl Med Mol Imaging. 2011;38:742–52.

    Article  PubMed  Google Scholar 

  2. Nanni C, Rubello D, Fanti S. Role of small animal PET for molecular imaging in pre-clinical studies. Eur J Nucl Med Mol Imaging. 2007;34:1819–22.

    Article  PubMed  Google Scholar 

  3. Ito M, Hong S, Lee J. Positron emission tomography (PET) detectors with depth-of-interaction (DOI) capability. Biomed Eng Lett. 2011;1:70–81.

    Article  Google Scholar 

  4. Blinder SAL, Dinelle K, Sossi V. Scanning rodents on the high resolution research tomograph (HRRT) with point spread function reconstruction: a feasibility study. In: IEEE Nuclear Science Symposium Conference Record (NSS/MIC). 2010, pp. 3333–8.

  5. de Jong HW, van Velden FH, Kloet RW, Buijs FL, Boellaard R, Lammertsma AA. Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner. Phys Med Biol. 2007;52:1505–26.

    Article  PubMed  Google Scholar 

  6. Varrone A, Sjöholm N, Eriksson L, Gulyás B, Halldin C, Farde L. Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT. Eur J Nucl Med Mol Imaging. 2009;36:1639–50.

    Article  PubMed  Google Scholar 

  7. Panin VY, Kehren F, Michel C, Casey M. Fully 3-D PET reconstruction with system matrix derived from point source measurements. IEEE Trans Med Imaging. 2006;25:907–21.

    Article  PubMed  Google Scholar 

  8. Scheins JJ, Herzog H, Shah NJ. Fully-3D PET image reconstruction using scanner-independent, adaptive projection data and highly rotation-symmetric voxel assemblies. IEEE Trans Med Imaging. 2011;30:879–92.

    Article  CAS  PubMed  Google Scholar 

  9. Tong S, Alessio AM, Kinahan PE. Noise and signal properties in PSF-based fully 3D PET image reconstruction: an experimental evaluation. Phys Med Biol. 2010;55:1453–73.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Knoess C, Siegel S, Smith A, Newport D, Richerzhagen N, Winkeler A, et al. Performance evaluation of the microPET R4 PET scanner for rodents. Eur J Nucl Med Mol Imaging. 2003;30:737–47.

    Article  PubMed  Google Scholar 

  11. Jakoby BW, Bercier Y, Watson CC, Bendriem B, Townsend DW. Performance characteristics of a new LSO PET/CT scanner with extended axial field-of-view and PSF reconstruction. Nucl Sci IEEE Trans Nucl Sci. 2009;56:633–9.

    Article  Google Scholar 

  12. NEMA. Performance measurements of positron emission tomographs. In: NEMA standards publication NU 2-2007. Rosslyn: NEMA; 2007.

  13. NEMA. Performance measurements of small animal positron emission tomographs. In: NEMA standards publication NU 4-2008. Rosslyn: NEMA; 2008.

  14. Selivanov VV, Picard Y, Cadorette J, Rodrigue S, Lecomte R. Detector response models for statistical iterative image reconstruction in high resolution PET. IEEE Trans Nucl Sci. 2000;47:1168–75.

    Article  Google Scholar 

  15. Lois C, Jacoby BW, Long MJ, Hubner KF, Barker DW, Casey ME, et al. An assessment of the impact of incorporating time-of-flight information into clinical PET/CT imaging. J Nucl Med. 2010;51:237–45.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Disselhorst JA, Brom M, Laverman P, Slump CH, Boerman OC, Oyen WJ, et al. Image-quality assessment for several positron emitters using the NEMA NU 4-2008 standards in the Siemens Inveon small-animal PET scanner. J Nucl Med. 2010;51:610–7.

    Article  PubMed  Google Scholar 

  17. Snyder DL, Miller MI, Thomas LJ, Politte DG. Noise and edge artifacts in maximum-likelihood reconstructions for emission tomography. IEEE Trans Med Imaging. 1987;6:228–38.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by grants from the Nuclear R & D Program (2012M2A2A7013722) of the Korea Science and Engineering Foundation funded by the Ministry of Education, Science and Technology. The authors would like to thank Dr. Bjoern Jakoby for constructive discussion.

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Authors and Affiliations

  1. Molecular Imaging Research Center, Korea Institute Radiological and Medical Sciences, 75 Nowon-gil, Gongneung-dong, Nowon-gu, Seoul, 139-706, Republic of Korea

    Young Sub Lee, Jin Su Kim, Kyeong Min Kim, Joo Hyun Kang & Sang Moo Lim

  2. Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Republic of Korea

    Young Sub Lee & Hee-Joung Kim

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  1. Young Sub Lee
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  2. Jin Su Kim
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  3. Kyeong Min Kim
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Correspondence to Jin Su Kim.

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Lee, Y.S., Kim, J.S., Kim, K.M. et al. Performance measurement of PSF modeling reconstruction (True X) on Siemens Biograph TruePoint TrueV PET/CT. Ann Nucl Med 28, 340–348 (2014). https://doi.org/10.1007/s12149-014-0815-z

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