Skip to main content
SpringerLink
Log in

Influence of left ventricular geometry on thallium-201 gated single-photon emission tomographic findings in patients with known or suspected coronary artery disease

  • Original Article
  • Published:
Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Background

Recent studies have shown good correlations between echocardiography and Tl-201 gated single-photon emission computed tomography (SPECT) for the assessment of left ventricular volumes and ejection fraction. We assessed how left ventricular geometry affected correlations between these values measured by the 2 methods in patients with known or suspected coronary artery disease.

Methods and results

There were 109 patients with normal left ventricular geometry, 20 patients with concentric remodeling, 32 patients with eccentric hypertrophy and 28 patients with concentric hypertrophy. In all 4 groups, there were good correlations between end-diastolic volume (EDV) and end-systolic volume (ESV) values measured by echocardiography and quantitative gated SPECT (QGS). EDV and ESV values measured by QGS were significantly underestimated than those measured by echocardiography except for ESV in eccentric hypertrophy. In all 4 groups, ejection fraction (EF) value measured by echocardiography significantly correlated with that measured by QGS, but Bland–Altman plot showed a proportional error. EF value measured by QGS was likely to be overestimated when EF value increased from the median value, and to be underestimated when EF value decreased from the median value especially in concentric remodeling.

Conclusions

Tl-201 gated SPECT is a useful tool for the assessment of left ventricular volumes and function, but it requires methodological considerations according to left ventricular geometry.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Yang KT, Chen HD. Evaluation of global and regional left ventricular function using technetium-99m sestamibi ECG-gated single-photon emission tomography. Eur J Nucl Med. 1998;25:515–21.

    Article  CAS  PubMed  Google Scholar 

  2. Yoshioka J, Hasegawa S, Yamaguchi H, Tokita N, Paul AK, Xiuli M, et al. Left ventricular volumes and ejection fraction calculated from quantitative electrocardiographic-gated 99mTc-tetrofosmin myocardial SPECT. J Nucl Med. 1999;40:1693–8.

    CAS  PubMed  Google Scholar 

  3. Rozanski A, Nichols K, Yao SS, Malholtra S, Cohen R, DePuey EG. Development and application of normal limits for left ventricular ejection fraction and volume measurements from 99mTc-sestamibi myocardial perfusion gates SPECT. J Nucl Med. 2000;41:1445–50.

    CAS  PubMed  Google Scholar 

  4. DePuey EG, Parmett S, Ghesani M, Rozanski A, Nichols K, Salensky H. Comparison of Tc-99m sestamibi and Tl-201 gated perfusion SPECT. J Nucl Cardiol. 1999;6:278–85.

    Article  CAS  PubMed  Google Scholar 

  5. Hyun IY, Kwan J, Park KS, Lee WH. Reproducibility of Tl-201 and Tc-99m sestamibi gated myocardial perfusion SPECT measurement of myocardial function. J Nucl Cardiol. 2001;8:182–7.

    Article  CAS  PubMed  Google Scholar 

  6. Bacher-Stier C, Müller S, Pachinger O, Strolz S, Erler H, Moncayo R, et al. Thallium-201 gated single-photon emission tomography for the assessment of left ventricular ejection fraction and regional wall motion abnormalities in comparison with two-dimensional echocardiography. Eur J Nucl Med. 1999;26:1533–40.

    Article  CAS  PubMed  Google Scholar 

  7. Cwajg E, Cwajg J, He ZX, Hwang WS, Keng F, Nagueh SF, et al. Gated myocardial perfusion tomography for the assessment of left ventricular function and volumes: comparison with echocardiography. J Nucl Med. 1999;40:1857–65.

    CAS  PubMed  Google Scholar 

  8. Patel CD, Nadig MR, Kurien S, Barai S, Narang R, Malhotra A. Left ventricular ejection fraction and volumes on rest gated 201Tl perfusion SPECT: comparison with two-dimensional echocardiography. Nucl Med Commun. 2006;27:425–9.

    Article  PubMed  Google Scholar 

  9. Harpaz D, Asman A, Kuperstein R, Boaz M, Chouraqui P. Left ventricular ejection fraction assessment by Tl-201 gated SPECT: a comparison with echocardiography. Clin Cardiol. 2010;33:E56–62.

    Article  PubMed  Google Scholar 

  10. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989;2:358–67.

    CAS  PubMed  Google Scholar 

  11. Otterstad JE, Froeland G, John Sutton M, Holme I. Accuracy and reproducibility of biplane two-dimensional echocardiographic measurements of left ventricular dimensions and function. Eur Heart J. 1997;18:507–13.

    Article  CAS  PubMed  Google Scholar 

  12. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Chamber Quantification Writing Group, American Society of Echocardiography’s Guidelines and Standards Committee, European Association of Echocardiography, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440–63.

    Article  PubMed  Google Scholar 

  13. Takasaki K, Miyata M, Imamura M, Yuasa T, Kuwahara E, Kubota K, et al. Left ventricular dysfunction assessed by cardiac time interval analysis among different geometric patterns in untreated hypertension. Circ J. 2012;76:1409–14.

    Article  PubMed  Google Scholar 

  14. Germano G, Kiat H, Kavanagh PB, Moriel M, Mazzanti M, Su HT, et al. Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med. 1995;36:2138–47.

    CAS  PubMed  Google Scholar 

  15. Wright GA, McDade M, Keeble W, Martin W, Hutton I. Quantitative gated SPECT myocardial perfusion imaging with 201Tl: an assessment of the limitations. Nucl Med Commun. 2000;21:1147–51.

    Article  CAS  PubMed  Google Scholar 

  16. El-Maghraby TA, El-Rahman NA. Clinical relevance of left ventricular volumes and function assessed by gated SPECT in paediatric patients. Int J Cardiovasc Imaging. 2004;20:127–34.

    Article  PubMed  Google Scholar 

  17. Germano G, Berman DS. On the accuracy and reproducibility of quantitative gated myocardial perfusion SPECT. J Nucl Med. 1999;40:810–3.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi-cho, Minami-ku, Hiroshima, 734-8551, Japan

    Satoshi Kurisu, Toshitaka Iwasaki, Hiroki Ikenaga, Noriaki Watanabe, Tadanao Higaki, Takashi Shimonaga, Ken Ishibashi, Naoya Mitsuba, Yoshihiro Dohi & Yasuki Kihara

Authors
  1. Satoshi Kurisu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Toshitaka Iwasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hiroki Ikenaga
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Noriaki Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tadanao Higaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Takashi Shimonaga
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ken Ishibashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Naoya Mitsuba
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yoshihiro Dohi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Yasuki Kihara
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Satoshi Kurisu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kurisu, S., Iwasaki, T., Ikenaga, H. et al. Influence of left ventricular geometry on thallium-201 gated single-photon emission tomographic findings in patients with known or suspected coronary artery disease. Ann Nucl Med 28, 120–127 (2014). https://doi.org/10.1007/s12149-013-0786-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12149-013-0786-5

Keywords

Search

Navigation