Abstract
Osteosarcoma is the most frequent primary malignancy of bone, and usually metastasizes to the lung and bones, while other sites are rare. In most reported cases, soft tissue metastasis of osteosarcoma is unusual, and only develops in the advanced stages of the disease, especially following multiple recurrences. We present a patient with recently diagnosed osteosarcoma of the right femur, showing abdominal wall metastasis diagnosed by technetium-99m-methylene diphosphonate (99m Tc-MDP) whole body bone scintigraphy and confirmed histologically. The present case highlights the importance of whole body imaging of patients with osteosarcoma for detecting unusual sites of metastasis, especially in soft tissue organs.
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References
Malawer MM, Helman LJ, O’Sullivan B. Sarcomas of bone. In: DeVita VT, Lawrence TS, Steven A R, editors. Cancer: principle and practice of oncology. 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2011: 1578–80.
Kim SJ, Choi JA, Lee SH, Choi JY, Hong SH, Chung HW, et al. Imaging findings of extrapulmonary metastases of osteosarcoma. Clin Imaging. 2004;28:291–300.
Giuliano AE, Feig S, Eilber F. Changing metastatic pattern of osteosarcoma. Cancer. 1984;54:2160–4.
Basu S, Moghe SH, Shet T. Metastasis of humeral osteosarcoma to the contralateral breast detected by 99mTc-MDP skeletal scintigraphy. Jpn J Radiol. 2009;27:455–7.
Ragsdale MI, Lehmer LM, Ragsdale BD, Chow WA, Carson RT. Cutaneous metastasis of osteosarcoma in the scalp. Am J Dermatopathol. 2011;33(6):e70–3.
Fernandez-Pineda I, Bahrami A, Green JF, McGregor LM, Davidoff AM, Sandoval JA. Isolated subcutaneous metastasis of osteosarcoma 5 years after initial diagnosis. J Pediatr Sur. 2011;46:2029–31.
Miki T, Yamamuro T, Kotoura Y, Matsushita M, Shimizu Y, Nakamura T. Osteosarcoma with multiple intramuscular metastases. Acta Orthop Scand. 1985;56:92–5.
Takesh M, Zoller H, Ghazi H, Zein M, Sahli H. Radionuclide detection of multiple soft tissue metastases of osteosarcoma masquerading as bone metastasis. Med Princ Pract. 2012;21:582–4.
Basu S, Desai SB. Solitary anterior abdominal wall metastasis from osteogenic sarcoma of fibula as detected by FDG-PET imaging. Cancer Res Therap. 2011;7(2):229–30.
Peh WC, Shek TW, Wang SC, Wong JW, Chien EP. Osteogenic sarcoma with skeletal muscle metastases. Skeletal Radiol. 1999;28:298–304.
Parlakian A, Gomaa I, Solly S, Arandel L, Mahale A, Born G, et al. Skeletal muscle phenotypically converts and selectively Inhibits metastatic cells in mice. PLoS ONE. 2012;5(2):e9299.
Plaza JA, Perez-Montiel D, Mayerson J, Morrison C, Suster S. Metastases to soft tissue: a review of 118 cases over a 30-year period. Cancer. 2008;112(1):193–203.
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Pirayesh, E., Rakhshan, A., Amoui, M. et al. Metastasis of femoral osteosarcoma to the abdominal wall detected on 99m Tc-MDP skeletal scintigraphy. Ann Nucl Med 27, 478–480 (2013). https://doi.org/10.1007/s12149-013-0708-6
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DOI: https://doi.org/10.1007/s12149-013-0708-6