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Assessment of atherosclerosis in oncologic patients using 18F-fluoride PET/CT

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Abstract

Objectives

The purpose of this study was to evaluate the prevalence, distribution, and relationship of 18F-fluoride uptake and arterial calcification in oncologic patients using 18F-fluoride PET/CT.

Methods

Image data obtained from 29 oncologic patients undergoing whole-body 18F-fluoride PET/CT were evaluated retrospectively. Arterial wall 18F-fluoride uptake and calcification were analyzed both quantitatively and semiquantitatively in 8 patients with arterial 18F-fluoride uptake.

Results

Arterial 18F-fluoride uptake was observed at 35 lesions in 8 (28 %) of the 29 patients, and calcification was observed at 345 lesions in the same patients. Five of the 8 patients had prostate cancer, and the remaining patients had hepatocellular carcinoma or malignant melanoma. In these 8 patients, the prevalence of both 18F-fluoride uptake and calcification was highest in the abdominal aorta, followed by the descending thoracic aorta and the aortic arch. Colocalization of radiotracer accumulation and calcification could be observed in the 32 lesions (91 %) with arterial 18F-fluoride uptake, and only the 3 lesions (9 %) with arterial 18F-fluoride uptake were not colocalized with arterial calcification. The presence of both arterial radiotracer uptake and calcification was significantly associated with advancing age (P < 0.01).

Conclusion

Our results suggest that 18F-fluoride PET/CT might be a useful modality for detecting active mineral deposition sites of atherosclerosis in oncologic patients.

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Authors and Affiliations

  1. Department of Radiology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, 830-0011, Japan

    Seiji Kurata, Hayato Kaida, Kiminori Fujimoto & Masatoshi Ishibashi

  2. Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Ukihide Tateishi, Kazuya Shizukuishi, Tomohiro Yoneyama, Ayako Hino & Tomio Inoue

Authors
  1. Seiji Kurata
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  2. Ukihide Tateishi
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  3. Kazuya Shizukuishi
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  4. Tomohiro Yoneyama
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  5. Ayako Hino
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  6. Hayato Kaida
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  7. Kiminori Fujimoto
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  8. Masatoshi Ishibashi
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  9. Tomio Inoue
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Correspondence to Seiji Kurata.

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Kurata, S., Tateishi, U., Shizukuishi, K. et al. Assessment of atherosclerosis in oncologic patients using 18F-fluoride PET/CT. Ann Nucl Med 27, 481–486 (2013). https://doi.org/10.1007/s12149-013-0706-8

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  • DOI: https://doi.org/10.1007/s12149-013-0706-8

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