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Benign fibrous dysplasia on [11C]choline PET: a potential mimicker of disease in patients with biochemical recurrence of prostate cancer

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Abstract

We present the case of a 74-year-old male with biochemical recurrence of prostate cancer who underwent [11C]choline PET/CT. The PET/CT demonstrated an intense focus of uptake within the skull base that was initially felt to potentially represent metastatic disease. Subsequent evaluation with MRI and dedicated thin-section CT revealed this area to be benign fibrous dysplasia of the bone. The focal uptake on PET/CT with [11C]choline in benign fibrous dysplasia represents a potential mimicker of metastatic disease. Due to recognizing this benign process, our patient was able to avoid systemic treatment and/or focal radiation and was treated with cryotherapy for biopsy-proven local recurrence within the prostate bed. While benign fibrous dysplasia can demonstrate increased radiotracer uptake on other modalities (i.e., bone scintigraphy, FDG PET/CT), its appearance on [11C]choline PET/CT has been largely overlooked in the literature. With the increasing use of [11C]choline PET/CT for biochemical recurrent prostate cancer evaluation, it is important to understand this potential mimicker of disease.

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Authors and Affiliations

  1. University of Missouri, Columbia School of Medicine, Columbia, MO, USA

    Chris N. Gu

  2. Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA

    Christopher H. Hunt, Vance T. Lehman, Geoffrey B. Johnson, Felix E. Diehn, Kara M. Schwartz & Laurence J. Eckel

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  1. Chris N. Gu
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  2. Christopher H. Hunt
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  3. Vance T. Lehman
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  4. Geoffrey B. Johnson
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  5. Felix E. Diehn
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  6. Kara M. Schwartz
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  7. Laurence J. Eckel
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Correspondence to Christopher H. Hunt.

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Gu, C.N., Hunt, C.H., Lehman, V.T. et al. Benign fibrous dysplasia on [11C]choline PET: a potential mimicker of disease in patients with biochemical recurrence of prostate cancer. Ann Nucl Med 26, 599–602 (2012). https://doi.org/10.1007/s12149-012-0610-7

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  • DOI: https://doi.org/10.1007/s12149-012-0610-7

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