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Comparison of Alzheimer’s disease with vascular dementia and non-dementia using specific voxel-based Z score maps

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Abstract

Objective

We investigated the ability to discriminate between Alzheimer’s disease (AD) and vascular dementia (VaD), and between AD and non-dementia using the program “easy Z score imaging system” (eZIS) developed by Matsuda et al., for the diagnosis of very early AD.

Methods

Of 201 patients, we investigated 12 patients with AD, 10 with VaD, and 9 with non-dementia, who underwent brain perfusion single-photon emission computed tomography by technetium-99m ethyl cysteinate dimer (99mTc-ECD) between February 2005 and September 2006. The sensitivity and specificity of the indicators of specific volume of interest (VOI) analysis, namely, severity, extent, and ratio were evaluated for the distinction of AD from VaD and non-dementia.

Results

There was a significant difference in all the criteria for severity, extent, and ratio between AD and non-dementia cases and in the ratio between AD and VaD. Between AD and non-dementia, the sensitivity and specificity of severity were 100% and 45%, respectively, using the cutoff value of 1.19. When using the cutoff value of 14.2 for extent, the sensitivity and specificity were both 100%. Using the cutoff value of 2.22 for ratio, the sensitivity of 42% and specificity of 100% were demonstrated. When comparing AD with VaD, using the cutoff value of 2.22 for ratio, the sensitivity and specificity were 42% and 100%, respectively. Using the cutoff value of 1.5 for ratio, the sensitivity and specificity between AD and VaD were 92% and 80%, respectively, thereby showing the best results.

Conclusions

The specific VOI analysis program of AD using specific voxel-based Z score maps is not influenced by interobserver differences among radiologists and is useful to discriminate AD from VaD and non-dementia. However, the setting of the cutoff value at each institution and comparison with original and eZIS images are suggested to distinguish better AD from VaD.

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References

  1. Minoshima S, Foster NL, Kuhl DE. Posterior cingulated cortex in Alzheimer’s disease. Lancet 1994;34:895.

    Article  Google Scholar 

  2. Minoshima S, Giordani B, Berent S, Frev KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulated cortex in very early Alzheimer’s disease. Ann Neurol 1997;42:85–94.

    Article  PubMed  CAS  Google Scholar 

  3. Homma A, Takeda M, Imai Y, Udaka F, Hasegawa K, Kameyama M, et al. Clinical efficacy and safety of donepezil on cognitive and global function in patients with Alzheimer’s disease. Dement Geriatr Cogn Disord 2000;11:299–313.

    Article  PubMed  CAS  Google Scholar 

  4. Mohs RC, Donny RS, Morris JC, Ieni JR, Rogers SL, Perdomo CA, et al. A 1-year, placebo-controlled preservation of function survival study of donepezil in AD patients. Neurology 2001;57:481–488.

    PubMed  CAS  Google Scholar 

  5. Winbland B, Kilander L, Eriksson S, Minthon L, Batsman S, Wetterholm AL, et al. Donepezil in patients with severe Alzheimer’s disease: double-blind, parallel-group, placebocontrolled study. Lancet 2006;367:1057–1065.

    Article  Google Scholar 

  6. Matsuda H, Mizumura S, Soma T, Takemura N. Conversion of brain SPECT images between different collimators and reconstruction processes for analysis using statistical parametric mapping: Nucl Med Commun 2004;25:67–74.

    Article  PubMed  CAS  Google Scholar 

  7. Kogre D, Matsuda H, Ohnishi T, Asada T, Uno M, Kunihiro T, et al. Longitudinal evaluation of early Alzheimer’s disease using brain perfusion SPECT. J Nucl Med 2000;41:1155–1162.

    Google Scholar 

  8. Herholz K, Schopphof H, Schmidt M, Mielke R, Escher W, Scheidhauer K, et al. Direct comparison of spatially normalized PET and SPECT scans in Alzheimer’s disease. J Nucl Med 2002;43:21–26.

    PubMed  Google Scholar 

  9. Imabayashi E, Matsuda H, Asada T, Ohnishi T, Sakamoto S, Nakano S, et al. Superiority of three-dimensional stereo-tactic surface projection analysis over visual inspection in discrimination of patients with very early Alzheimer’s disease from controls using brain perfusion SPECT. J Nucl Med 2004;45:1450–1457.

    PubMed  Google Scholar 

  10. Bonte FJ, Harris TS, Roney CA, Hynan LS. Differential diagnosis between Alzheimer’s and frontotemporal disease by posterior cingulated sign. J Nucl Med 2004;45:771–774.

    PubMed  Google Scholar 

  11. Johnson KA, Jones K, Holman BL, Becker JA, Spiers PA, Satlin A, et al. Preclinical prediction of Alzheimer’s disease using SPECT. Neurology 1998;50:1563–1671.

    PubMed  CAS  Google Scholar 

  12. Ushijima Y, Okumura C, Mori S, Kubota T, Nakai T, Nishimura T. Regional cerebral blood flow in Alzheimer’s disease: comparison between short and long term donepezil therapy. Ann Nucl Med 2006;20:425–429.

    Article  CAS  Google Scholar 

  13. Matsuda H, Mizushima S, Nagao T, Ota T, Iizuka T, Nemoto K, et al. Automated discrimination between very early Alzheimer’s disease and controls using easy Z-score imaging system for multicenter brain perfusion SPECT. Am J Neuroradiol AJNR 2007;28:731–736.

    CAS  Google Scholar 

  14. Honda N, Machida K, Hosono M, Matsumoto T, Matsuda H, Oshima M, et al. Interobserver variation in diagnosis of dementia by brain perfusion SPECT. Radiat Med 2002;20:281–289.

    PubMed  Google Scholar 

  15. Mckhann G, Drachman D, Folstein M, Katzman R, Price D, Emanuel M, et al. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the autopsies of Department of Health and Human Service Task Force on Alzheimer’s disease. Neurology 1984;34:939–944.

    PubMed  CAS  Google Scholar 

  16. Roman GC, Tatemichi T, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN international workshop. Neurology 1993;43:250–260.

    Article  PubMed  CAS  Google Scholar 

  17. Van Heertum RL, Tikofsky RS. Positron emission tomography and single-photon emission computed tomography brain imaging in the evaluation of dementia. Semin Nucl Med 2003;33:77–85.

    Article  PubMed  Google Scholar 

  18. Dougal NJ, Brugink S, Ebmeier KP. Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia. Am J Geriatr Psychiatry 2004;12:554–570.

    Google Scholar 

  19. Michel D, Devous Sr. Functional brain imaging in the dementias: role in early detection, differential diagnosis, and longitudinal studies. Eur J Nucl Med 2002;29:1685–1696.

    Article  Google Scholar 

  20. Masterman DL, Mendez MF, Fairbanks LA, Cummings JL. Sensitivity specificity and positive predictive value of technetium 99-HMPAO SPECT in discriminating Alzheimer’s disease from other dementias. J Geriatr Psychiatry Neurol 1997;10:15–21.

    PubMed  CAS  Google Scholar 

  21. Johnson KA, Kijewski MF, Becker JA, Garada B, Saltlin A, Holman BL. Quantitative brain SPECT in Alzheimer’s disease and normal aging. J Nucl Med 1993;34:2044–2048.

    PubMed  CAS  Google Scholar 

  22. Stoppe G, Staedt J, Kogler A, Schutze R, Kunert HJ, Sandrock D, et al. 99mTc-HMPAO-SPECT in the diagnosis of senile dementia of Alzheimer’s type: a study under clinical conditions. J Neural Transm 1995;99:195–211.

    Article  CAS  Google Scholar 

  23. Villa G, Cappa A, Tavolozza M, Gainotti G, Giordano A, Calcagni ML, et al. Neuropsychological tests and 99mTc-HMPAO-SPECT in the diagnosis of Alzheimer’s dementia. J Neurol 1995;242:359–366.

    Article  PubMed  CAS  Google Scholar 

  24. Mizumura S, Kumita S, Cho K, Ishihara M, Nakajo H, Toba M, et al. Development of quantitative analysis method for stereotactic image: assessment of reduced accumulation in extent and severity using anatomical segmentation. Ann Nucl Med 2002;43:21–26.

    Google Scholar 

  25. Herholz K, Salmon E, Perani D, Baron JC, Holthoff V, Frolich L, et al. Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 2002;17:302–316.

    Article  PubMed  CAS  Google Scholar 

  26. Hirata Y, Matsuda H, Nemoto K Ohnishi T, Hirao K, Yamashita F, et al. Voxel-based morphometry to discriminate early Alzheimer’s disease from controls. Neurosci Lett 2005;382:269–274.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Fukusuhima Medical University Hospital, 1 Hikarigaoka, Fukushima, 960-1295, Japan

    Shirou Ishii, Fumio Shishido, Masayuki Miyajima, Koutarou Sakuma, Takeshi Shigihara, Tadanobu Tameta & Makoto Miyazaki

  2. Department of Neurology, Iwaki Kyoritsu Hospital, Iwaki, Fukushima, Japan

    Hiroshi Kuroda

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  1. Shirou Ishii
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  2. Fumio Shishido
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  3. Masayuki Miyajima
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  4. Koutarou Sakuma
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  5. Takeshi Shigihara
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  6. Tadanobu Tameta
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  7. Makoto Miyazaki
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  8. Hiroshi Kuroda
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Correspondence to Shirou Ishii.

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Ishii, S., Shishido, F., Miyajima, M. et al. Comparison of Alzheimer’s disease with vascular dementia and non-dementia using specific voxel-based Z score maps. Ann Nucl Med 23, 25–31 (2009). https://doi.org/10.1007/s12149-008-0210-8

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  • DOI: https://doi.org/10.1007/s12149-008-0210-8

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