Abstract
Objective
The aim of this work was to study the effectiveness of 32P colloids or microspheres, by arterial interventional administration or stromal injection in the treatment of refractory solid tumors.
Methods
By arterial intervention, under the guidance of computerized tomography, X-ray, ultrasonogram, or under direct vision of the surgical field, 32P microspheres (259–685 MBq) or radioactive colloid (281–666 MBq) was administered to 60 cases with refractory solid tumors. Tumor inhibition rate, side effects, survival period, and so on were observed.
Results
The tumor growth was obviously inhibited after the intratumoral injection of 32P colloid. The average survival time in the 60 cases was 35 months with a high tumor inhibition rate (93.4%). Thirty-one cases were completely relieved (51.7%), and 25 cases achieved partial remission (PR, 41.7%). One case with right lobe hepatocellular carcinoma has survived 90 months. The drug was ineffective only in four cases, including one patient who died of gastrointestinal hemorrhage and three of hepatic failure. No other obvious side effects were observed. Intratumoral necrosis, intense fibrosis in the tumor mass, and an integrated capsule encompassing the tumor were revealed by histological examination.
Conclusions
Arterial interventional administration or stromal injection with 32P microspheres or colloid revealed a very fair clinical effectiveness in the treatment of refractory solid tumors. The range of safe effective dosage for 32P glass microspheres and 32P chromic phosphate in one treatment course is 555–740 MBq and 185–370 MBq, respectively.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Liu L, Teng GJ, Jiang Z, Song JZ, Zhang DS, Guo QM, et al. Clinical and experimental study on regional administration of phosphorus-32 glass microspheres in treating hepatic carcinoma. World J Gastroenterol 1999;5:492–505.
Liu L, Wang ZZ, Gao H, Li XD, Ying QH, Huang Y. Study on the effects of focal injection of 32P-chromic phosphate colloid on pancreatic carcinoma (Pc-3) and its radioactivity in the lymph node. Chin J Nucl Med 2003;23:334–336.
ICRP publication 53. Radiation dose to patients from radiopharmaceuticals. Ann ICRP 1988;28:1–126.
Li SJ. Dosimetry of ionized radiation (in Chinese). Beijing: Atomic Energy Press; 1986.
Menon C, Polin GM, Prabakaran I, Hsi A, Cheung C, Culver JP, et al. An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model. Cancer Res 2003;63:7232–7240.
Tu JT, Wu CE, Feng XS. Common statistical indexes and methods in diagnosis and treatment of tumor (in Chinese). Beijing: Beijing Medical University and Chinese Peking Union University Association Press; 1991.
Li J, Wang L, Ye HJ, Li FE. Effects of the union treatment of the transcatheter arterial embolization (TAE) and percutaneous ethanol injection therapy (PEIT). Clin J Hepatobiliary Dis 2002;18:161–162.
Liu L, Teng GJ, Jiang Z, He SC, Xie SL, Wu LS, et al. Preliminary application of 32P glass microspheres interventional therapy in treating hepatocellular carcinoma. Nucl Technology 2000;23:316–322.
Li LJ, Feng GS, Liu L, Gao H, Yang DT, Zhang WZ. Combined implantation of 125I seed and slow releasing fluorouracil in targeting treatment of pancreatic carcinoma in progressive stage. Trans Southeast Univ 2004;23:246–247.
Liu L. Artery radionuclide intervention therapy. In: Pan ZY, editor. PET imaging and radionuclide therapy (in Chinese). Beijing: People’s Medical Publishing House; 2004. p. 533–546.
Liu L, Tong GS, Wang Y. Radioactive microspheres arterial interventional therapy for hepatocellular carcinoma. In: Pan ZY, editor. Radionuclide therapeutics (in Chinese). Beijing: People’s Medical Publishing House; 2006. p. 342–355.
Gao W, Liu L, Yin QH, Wang ZZ, Wang Y, Duan MH, et al. Biodistribution pharmacokinetics and toxic effect of P-32 chromic phosphate colloids interstitially injected into human pancreatic cancer (Pc-3)-bearing nude mice. Chin J Radiol Med Prot 2004;24:23–25.
Wang Y, Liu L, Duan MH, Tong GS, Liu L. Study on the apoptosis and expression of correlated genes induced by 32P chromic phosphate colloid on grafted pancreatic carcinoma Pc-3 in nude mice. Chin J Nucl Med 2003;23:294–296.
Firusian N, Dempke W. An early phase II study of intratumoral P-32 chromic phosphate injection therapy for patients with refractory solid tumors and solitary metastases. Cancer 1999;85:980–987.
Li XD, Liu L, Liu ZY, Ma C, Wang Y, Xie YS, et al. Interstitial irradiation using 32P-chromic phosphate during resection of cardio-esophageal carcinoma. Chin J Radiol Med Prot 2004;5:302–305.
Dempke W, Grothey A, Schmoll HJ. Therapeutic management of pleural and pericardial effusions. Onkologie 1999;22:526–529.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gao, W., Liu, L., Teng, GJ. et al. Internal radiotherapy using 32P colloid or microsphere for refractory solid tumors. Ann Nucl Med 22, 653–660 (2008). https://doi.org/10.1007/s12149-008-0176-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12149-008-0176-6