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MYB-NFIB Translocation by FISH in Adenoid Cystic Carcinoma of the Head and Neck in Nigerian Patients: A Preliminary Report

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Abstract

Adenoid cystic carcinoma (AdCC) is a relatively rare malignancy of head and neck sites such as the salivary glands, lacrimal gland, sinonasal region, and pharynx and may arise in other exocrine glands. The oncologic event in AdCC is the translocation between MYB proto-oncogene transcription factor (MYB) and nuclear factor I/B (NFIB) resulting in t(6;9)(q22-23;p23-24). We carried out a preliminary evaluation of MYB-NFIB translocation by fluorescence in-situ hybridization on seven archived formalin-fixed paraffin-embedded tissues of AdCC of Nigerian patients and its clinicopathologic features. Only 3 of the 7 cases were successfully hybridized, all featuring MYB-NFIB translocations with a range of 14.7–83.3% of translocated cells in 60 cells examined. The 3 translocation positive cases were located in the maxillary sinus, buccal mucosa and parotid. Their morphologic appearances were cribriform-solid (1) & cribriform (2) and classified as grades III (1) & I (2), respectively. These patients may potentially benefit from MYB-targeted anti-neoplastic therapy.

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Funding

All authors declare that there are no financial conflicts associated with this study and that the funding source has no role in conceiving and performing the study. No funding to declare.

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Author notes

  1. Adepitan A. Owosho and Olufunlola M. Adesina are Co-equal first authors.

Authors and Affiliations

  1. Missouri School of Dentistry, A.T. Still University, 800 W Jefferson Street, Kirksville, Missouri, 63501, USA

    Adepitan A. Owosho, Robert Bauer & Kallie Holte

  2. Department of Oral and Maxillofacial Surgery and Oral Pathology, Faculty of Dentistry, Obafemi Awolowo University, Ile-Ife, Nigeria

    Olufunlola M. Adesina & Olujide O. Soyele

  3. Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria

    Oluwole Odujoko & Akinwumi Komolafe

  4. Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Kurt F. Summersgill

Authors
  1. Adepitan A. Owosho
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  2. Olufunlola M. Adesina
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  3. Oluwole Odujoko
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  4. Olujide O. Soyele
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  5. Akinwumi Komolafe
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  6. Robert Bauer
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Correspondence to Adepitan A. Owosho.

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The authors declare that they have no potential conflicts of interest.

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This study was exempt from review by the Institutional Review Board of A.T. Still University and Obafemi Awolowo University as no human or animal subject were utilized in this study. Formal written informed consent was not required as this study did not utilize human subjects.

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Owosho, A.A., Adesina, O.M., Odujoko, O. et al. MYB-NFIB Translocation by FISH in Adenoid Cystic Carcinoma of the Head and Neck in Nigerian Patients: A Preliminary Report. Head and Neck Pathol 15, 433–437 (2021). https://doi.org/10.1007/s12105-020-01214-3

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  • DOI: https://doi.org/10.1007/s12105-020-01214-3

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