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Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla

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Abstract

Calcifying epithelial odontogenic tumor (CEOT) is an uncommon locally invasive epithelial odontogenic tumor of the jaws associated with amyloid production. Intraosseous presentations are most common and they frequently occur in the posterior mandible. A non-calcifying Langerhans cell-rich variant of CEOT (NCLC CEOT) has been described with predilection for the anterior maxilla. Interestingly, all reported cases of NCLC CEOT have occurred in Asian population. We present a case of a 43-year old Caucasian female with a large radiolucent lesion involving the left anterior maxilla with histologic features of NCLC CEOT. This is the first reported case of this rare variant of CEOT in a Caucasian individual.

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Authors and Affiliations

  1. Divison of Oral and Maxillofacial Pathology and Radiology, The Ohio State University College of Dentistry, Columbus, OH, USA

    Neetha Santosh, Kristin K. McNamara & John R. Kalmar

  2. Department of Oral Pathology, Radiology and Medicine, Indiana University School of Dentistry, Indianapolis, IN, USA

    Neetha Santosh

  3. Department of Pathology & Laboratory Medicine, The Ohio State University Wexner Medical Center, 410 West 10th Avenue, Columbus, OH, 43210, USA

    O. Hans Iwenofu

Authors
  1. Neetha Santosh
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  2. Kristin K. McNamara
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  3. John R. Kalmar
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  4. O. Hans Iwenofu
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Correspondence to O. Hans Iwenofu.

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Santosh, N., McNamara, K.K., Kalmar, J.R. et al. Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla. Head and Neck Pathol 13, 718–721 (2019). https://doi.org/10.1007/s12105-018-0958-7

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  • DOI: https://doi.org/10.1007/s12105-018-0958-7

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